Shunzhi fifteen years (1658), Jinshi. After learning, he was sent to Zhangde, Henan Province (namely Anyang City) as an official, and later transferred to the magistrate of Chenggu County, Shaanxi Province, from which the auspicious symbol was made.

In the seventeenth year of Kangxi (1678), he was given a scholarship and reinstated. Soon after, he dismissed from office and returned to his study to write. In the 23rd year of Kangxi (1682), entrusted by the Governor of Zhejiang Province, he majored in Zhejiang Tongzhi and was hired as the president. A preface to Zhejiang Tongzhi has been handed down from generation to generation. Later, he edited Yanzhou County Records.

Mao Jike is good at classical Chinese. At the same time, Mao Qiling and Mao Shuxian are both from Zhejiang, so they are called "three hairs in the middle of Zhejiang, three nobles in the text". In his later years, he presided over his hometown academy, and countless people from far and near came to consult. In the forty-seventh year of Kangxi (1707), he died in his hometown at the age of 76.