Auricularia auricula can accelerate the catabolism and transportation of cholesterol in the body. The excretion of feces and bile increases, that is, the excretion of cholesterol increases. Because cholesterol synthesized (endogenous) and ingested (exogenous) in vivo is decomposed into acidic cholic acid and bound bile.
Acid is discharged into the duodenum through bile, and part of it is excreted. The liver oxidizes cholesterol into cholic acid every day and then synthesizes cholate, which accounts for about half of the whole body cholesterol; Neutral cholic acid, namely fecal sterols and fecal steroids, is excreted from feces. Therefore, the feces and bile of auricularia auricula group animals
The increase of juice excretion indicates that cholesterol excretion in the body increases, so auricularia auricula has the effect of lowering blood lipid. In addition, the comparison of serum LCAT activity and cholesterol transport law of three groups of animals further showed that Auricularia auricula could promote cholesterol metabolism, and LCAT could promote gallbladder consolidation.
An important alcohol transporter. The increase of its activity means that the cholesterol in the body is transported quickly through a mouthful of L-C. The cholesterol transport law of auricularia auricula group is close to that of normal group, and its regulation ability is higher than that of high cholesterol group. This also shows that in the case of cholesterol load, blackwood
Auricularia auricula can promote transportation and excretion, mainly because Auricularia auricula contains high crude fiber, unsaturated fatty acids and trace elements such as selenium, calcium and magnesium. It has the effects of reducing blood lipid and anti-atherosclerosis.
2. Auricularia auricula also has anti-lipid peroxidation effect. After taking auricularia auricula, the content of lipid peroxide NDA decreased significantly, which was significantly lower than that of high cholesterol group. Free radical scavenger SOD in aortic arch tissue of auricularia auricula group
Its activity is obviously higher than that of high cholesterol group and normal group, and its nerve activity is enhanced, which not only shows that the degree of lipid peroxidation in tissues is reduced, but also shows that the ability of scavenging free radicals is enhanced, because lipid peroxidation products and free radicals have damage to tissues and cells? And can promote
It can be seen that the above products can damage vascular endothelial cells and promote the formation of atherosclerotic plaques. Therefore, the degree of atherosclerosis in auricularia auricula group is obviously lighter than that in other groups. It is suggested that auricularia auricula not only has anti-atherosclerosis effect.
Chemical action, but also has anti-aging effect, mainly because of the high content of vitamins [and unsaturated fatty acids] in auricularia auricula.
To sum up, Auricularia auricula can promote cholesterol metabolism and excretion, reduce blood lipid and resist lipid peroxidation, and hyperlipidemia and lipid peroxidation products are important factors to promote the formation of atherosclerotic plaques. Therefore, Auricularia auricula has anti-atherosclerosis effect.
Chemical effects,
Defendant: zsby- first grade of probation 12-9 16:57.
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The discovery of Auricularin prevented blood thickening from entering a new stage of development.
Auricularia auricula (Auricularia auricula), "cutting with medicinal properties" day: Auricularia auricula moistens dryness, benefits intestines, nourishes blood, fights hunger and promotes blood circulation. Hong Zhaoguang, a famous cardiologist in China, said: "Auricularia auricula is very good, which can reduce blood viscosity and is not easy to get cerebral thrombosis and coronary heart disease." . Modern medical research shows that auricularia auricula is rich in polysaccharide and adenosine. Regular consumption of auricularia auricula can reduce thrombosis, alleviate coronary atherosclerosis and prevent thrombosis. According to the research of doctoral tutors of ammer shcmidt and Mahja University, Auricularia auricula in China can inhibit platelet aggregation due to the existence of adenosine (9-P-D bofUranosyl adenine). The postdoctoral research center of Zhongshengbeiyao International Pharmaceutical Company has proved through long-term experiments that 9-β- ribofuranosyl adenine, the effective component in Auricularia auricula, is a water-soluble low-molecular substance, which passes through the intestine as a whole and is directly inhaled into the blood by the intestinal epithelial layer. It has some activities and functions of enzymes and is named "Auricularia auricula". It is the strongest platelet aggregation inhibitor found in the world so far. American medical scientists predict that in the near future, the application of auricularia auricula, a bioactive substance, in the treatment of cardiovascular and cerebrovascular diseases will be as common as penicillin, and the development of fungal medicine will have a far-reaching impact on future medicine.
As we all know, water pipes will grow "scale", and human blood vessels will also produce "blood scale" like water pipes. With the increase of age, harmful cholesterol will deposit on the inner wall of blood vessels, forming "blood scale". Excessive blood scale deposition will reduce and harden the elasticity of the inner wall of blood vessels, induce diseases such as hypertension, coronary heart disease and cerebral thrombosis, and even cause death. Auriculin (9-β-dribofuranosyl adenine) contains blood-clearing and blood-dispersing factors, which can transport "blood dirt" and "garbage" deposited on the blood vessel wall to the outside of the blood vessel. Figuratively speaking, it is a magic car to remove blood stains and garbage in blood vessels. Each blood-clearing and blood-dispersing factor has a certain amount of blood stains and garbage. Not only will there be no "blood stain" deposition, but blood vessels and blood will be cleaned up more and more. The postdoctoral research center of traditional Chinese medicine found that the 9-6-D-door Beaufort glycosyl adenosine extracted by biotechnology is a water-soluble low molecular weight substance and several water-soluble heat-resistant substances with molecular weight less than 10000 dalton. It can obviously prolong prothrombin time and inhibit platelet aggregation concentration, which proves that Auricularia auricula is a powerful platelet aggregation inhibitor and can be completely absorbed by small intestine, but the active substance does not inhibit the function of platelet cyclooxygenase.
Auricularia auricula, a medicinal fungus.
Nutritional components: According to modern scientific analysis, every100g of dried product contains protein10.6g, fat 0.2g, carbohydrate 65g, crude fiber 7g, calcium 375mg, phosphorus 20 1 mg, iron185mg and vitamin B/kloc. The contents of protein, vitamins and iron are twice, twice to five times higher than those of auricularia auricula. There are many kinds of amino acids in protein, especially lysine and leucine.
Active ingredients: Auricularia auricula fruiting body contains acidic mucopolysaccharide, which is composed of monosaccharides such as L fucose, L arabinose, D- xylose, D- glucose, glucuronic acid, etc., and it is gray and filamentous.
Auricularia auricula contains adenosine (99 p D- furanosyl adenine), which is a water-soluble low molecular substance and a powerful platelet aggregation inhibitor. In addition, it also contains several water-soluble heat-resistant substances with molecular weight less than 10000 dalton, which also have similar biological activities.
Auricularia auricula melanin is a kind of colored polysaccharide peptide, which consists of glucose, mannose, galactose, fucose and a short peptide chain. When these components are decomposed into monosaccharides, they are colorless and soluble in water, and have physiological activities to enhance the immune function of the body. Adustin isolated from the fruiting body of Auricularia auricula has antifungal effect.
The phospholipids contained in dried auricularia auricula are lecithin, cephalin and sphingomyelin. Sterols are ergosterol (ergosterol 0 1) and 22:23- dihydroergosterol (22. 23, dihydroergosterol); In addition, it also contains a variety of physiologically active inorganic elements and vitamins, especially rich in iron.
Function of nature and taste: sweet, flat and non-toxic. Entering the stomach, liver and large intestine meridians, it can replenish qi and blood, stop bleeding, moisten the lungs and stomach, moisten dryness and intestines, relax muscles and tendons, and strengthen the body. Can be used for treating blood deficiency and qi deficiency, leg tremor, lung deficiency, cough, hemoptysis, hematemesis, epistaxis, postpartum weakness, leukorrhagia, metrorrhagia, bloody dysentery, intestinal wind hemorrhoid, constipation, and traumatic injury.
pharmacological action
1, hypoglycemic effect Auricularia auricula polysaccharide can prevent and treat hyperglycemia in alloxan diabetic mice, improve the glucose tolerance and tolerance curve of experimental mice, and reduce the drinking water of diabetic mice.
2. Hypolipidemic effect Auricularia auricula polysaccharide can obviously reduce the contents of serum free cholesterol, cholesterol lipid, triacylglycerol and 9- lipoprotein in hyperlipidemia rats, and reduce the formation of hypercholesterolemia in mice caused by high cholesterol.
3. Inhibition of platelet aggregation Adenosine and several related water-soluble low molecular substances can obviously prolong the time of inhibition of platelet aggregation by prothrombin concentration, which proves that adenosine is a powerful platelet aggregation inhibitor. It can be completely absorbed by the small intestine, but the active substance does not affect the synthesis of thromboxane by [14C] arachidonic acid, indicating that the substance does not inhibit the function of platelet cyclooxygenase.
4. Antithrombotic Auricularia auricula polysaccharide can obviously prolong the formation time of specific thrombus and fibrin thrombus in rabbits, shorten the length of thrombus, reduce the wet and dry weight of thrombus, reduce the number of platelets, reduce the adhesion rate of platelets and blood viscosity, obviously shorten the euglobulin lysis time of guinea pigs, reduce the content of plasma fibrinogen and improve the activity of fibrinolytic enzyme, which has obvious antithrombotic effect.
5, improve the immune function of the body Auricularia auricula polysaccharide can obviously promote the immune function of the body, including improving the spleen index, semi-hemolysis value and rosette formation rate, promoting macrophage phagocytosis and lymphocyte transformation rate, improving the cellular immunity and humoral immunity of the body, and has significant anti-tumor activity.
6. Anti-aging effect Auricularia auricula polysaccharide can reduce the brown finger content in myocardial blood tissue of mice, increase the activity of superoxide dismutase in brain and liver, and inhibit the activity of monoamine oxidase B (HA0-B) in isolated brain of mice, suggesting that Auricularia auricula polysaccharide has anti-aging activity.
7. Auricularia auricula polysaccharide has a protective effect on tissue injury, which can obviously enhance the metabolism of nucleic acid and protein, increase the content of liver microsomes, promote the biosynthesis of serum proteins, enhance the body's disease resistance and protect the body from injury.
8. Improving myocardial hypoxia Auricularia auricula polysaccharide can prolong the survival time and improve the survival rate of rats compared with normal pressure hypoxia tolerance test, suggesting that Auricularia auricula polysaccharide can improve the imbalance between oxygen supply and demand in ischemic myocardium.
9. Anti-ulcer effect Auricularia auricula polysaccharide can obviously inhibit the formation of stress ulcer in rats and promote the healing of acetic acid gastric ulcer.
10, anti-radiation effect Auricularia auricula polysaccharide has better anti-radiation effect than Tremella fuciformis polysaccharide, and can resist leukopenia caused by cyclophosphamide.
Study on Hypolipidemic and Anti-atherosclerosis Mechanism of Auricularia auricula
To explore the mechanism of auricularia auricula in reducing blood lipid and preventing atherosclerosis: mainly observe the changes of cholesterol metabolism and lipid peroxidation index. The experimental results showed that cholesterol metabolism and transport in Heitai group were accelerated. The excretion of bile and feces increased, and the lipid peroxidation procedure decreased obviously, so the degree of atherosclerosis was also reduced.
Auricularia auricula; Blood lipids; atherosclerosis
Experimental method (omitted)
Experimental results (omitted)
The experimental conclusion is 1. Auricularia auricula can accelerate the catabolism and transportation of cholesterol in the body, and the excretion of feces and bile increases, that is, the excretion of cholesterol increases. Cholesterol synthesized (endogenous) and ingested (exogenous) in the body is decomposed into acidic cholic acid and bound cholic acid, which are discharged into the duodenum through bile and partially discharged from the body. The liver oxidizes cholesterol into cholic acid every day to synthesize cholate, accounting for about half of the whole body cholesterol. However, neutral cholic acid, namely fecal sterol and fecal sterol, is excreted from feces. Therefore, the excretion of feces and bile in the auricularia auricula group increased, indicating that the excretion of cholesterol in the body increased, so auricularia auricula has the effect of lowering blood lipid. In addition, the comparison of serum LCAT activity and cholesterol transport law of three groups of animals showed that auricularia auricula could promote cholesterol metabolism, and LCAT was an important enzyme to promote cholesterol transport. The increase of its activity means that the cholesterol in the body is transported quickly through a mouthful of L-C. The cholesterol transport law of auricularia auricula group is close to that of normal group, and its regulation ability is higher than that of high cholesterol group. It also shows that Auricularia auricula can promote transportation and excretion under the condition of cholesterol load, mainly because Auricularia auricula contains high crude fiber, unsaturated fatty acids and trace elements, such as selenium, calcium, magnesium, etc., which has the effects of reducing blood fat and resisting atherosclerosis.
2. Auricularia auricula also has anti-lipid peroxidation effect. After taking auricularia auricula, the content of lipid peroxide NDA decreased significantly, which was significantly lower than that of high cholesterol group. The activity of free radical scavenger SOD in aortic arch tissue of auricularia auricula group was significantly higher than that of high cholesterol group and normal group, and the nerve activity was enhanced, which not only showed that the degree of lipid peroxidation in tissue was reduced, but also showed that the ability of scavenging free radicals was enhanced, because lipid peroxidation products and free radicals were harmful to tissues and cells? It can also promote cell aging and death, so it can be seen that the above products can damage vascular endothelial cells and promote the formation of atherosclerotic plaques. Therefore, the degree of atherosclerosis in auricularia auricula group is obviously lighter than that in other groups. It is suggested that auricularia auricula not only has anti-atherosclerosis effect, but also has anti-aging effect, mainly because of the high content of vitamins and unsaturated fatty acids in auricularia auricula
To sum up, Auricularia auricula can promote cholesterol metabolism and excretion, reduce blood lipid and resist lipid peroxidation, and hyperlipidemia and lipid peroxidation products are important factors to promote the formation of atherosclerotic plaques. Therefore, Auricularia auricula has anti-atherosclerosis effect,
Clinical study on lowering blood lipid and thrombosis of auricularia auricula polysaccharide soft capsule
Select 50 patients with clinical hyperlipidemia. The serum total cholesterol (generation) was 6.50 MMO11,and the target protein (β-LP) was above 6.00g/ 1. The patient took two auricularia auricula soft capsules every morning and evening for two months, and did not receive any lipid-lowering and anticoagulant drugs during the observation period. The decrease of platelet aggregation rate is more significant. This shows that Auricularia auricula soft capsule has many functions, such as reducing blood lipid, preventing thrombosis and inhibiting platelet aggregation, which is of great significance to the prevention and treatment of coronary heart disease and atherosclerosis.
Auricularia auricula soft capsules; Blood lipid thrombosis; Platelet aggregation; hyperlipoidemia
Experimental method (omitted)
Experimental results (omitted)
Conclusion Auricularia auricula soft capsule has good effects of reducing blood lipid, preventing thrombosis and inhibiting platelet aggregation. Therefore, taking auricularia auricula soft capsules for a long time is of great significance for the prevention and treatment of coronary heart disease and cardiovascular and cerebrovascular diseases. Taking Auricularia auricula soft capsules for a long time is good for health, especially for the elderly, because Auricularia auricula soft capsules also have anti-lipid peroxidation and anti-free radical effects, which has a certain effect on preventing aging.
Mechanism of auricularia auricula soft capsules: 1. Mechanism of Auricularia auricula soft capsule: The crude fiber content in Auricularia auricula is higher than that in general food, which can increase cholesterol excretion, which is also confirmed by animal experiments. Animal experiments show that cholesterol transport in the body is accelerated, and its decomposition and excretion are increased. In addition, the content of linoleic acid in auricularia auricula is high, accounting for 35.2% of fatty acids.
2. Auricularia auricula soft capsules can prevent thrombosis and platelet aggregation, mainly because Auricularia auricula contains adenosine with molecular weight of 1e000 dalton, which can affect the function of platelets and inhibit the release of arachidonic acid from phospholipids on platelet membranes, thus inhibiting the synthesis of thromboxane (TXA2). TXA2 is the strongest platelet aggregation agent and vasoconstrictor known at present. Because the aggregation of platelets is greatly reduced, thrombosis is also reduced. The anticoagulant mechanism of aspirin is to inhibit the production of TXA2 by inhibiting TXA2 synthase and acetylating it, thus achieving the effects of anti-platelet aggregation and anti-thrombosis. The results of animal experiments show that Auricularia auricula has similar effects to aspirin, suggesting that Auricularia auricula has high contents of vitamins [and selenium] and iron, and has anti-lipid peroxidation and anti-free radical effects, so it is still a good blood-nourishing food. Therefore, the elderly often eat black fungus soft capsules, which is beneficial to anti-aging.