The six national characteristic majors of Henan Normal University are economics, environmental engineering, mathematics and applied mathematics, chemistry, biological science and physics, among which chemistry, life science, physical psychology and teacher education also have national experimental teaching demonstration centers; Environmental science and engineering, chemistry, biology and physics have Post-Doctoral Research Center.

In addition, there are economics, politics, Marxist theory, education, physical education, China language and literature, foreign language and literature, China history, mathematics, physics, chemistry, biology, ecology, statistics, optical engineering, electronic science and technology, computer science and technology, chemical engineering and technology, environmental science and engineering, aquatic products, business administration, music and dance.

The liberal arts majors of Henan Normal University are all in the College of Liberal Arts, including Chinese language and literature, teaching Chinese as a foreign language, and radio and television news.