Basic uses: Inhibit nitric oxide synthase (nNOS) in neurons. Binding and precipitating DNA；; It is also used to purify DNA binding proteins. Stimulate T4 polynucleotide kinase activity. Spermidine is a natural substance, which may prevent the decline of age-related memory ability, which is the result of cooperative research between German and Austrian scientists. 2065438+September 2003 1 day, this achievement was published in the online edition of Nature Neuroscience.

Professor Stephen Seacrest of Free University in Berlin, Germany and Professor Frank Madeo of Karl Franzens University in Austria cooperated in this research. The results showed that spermidine could restore the brain performance of old Drosophila to the level of youth. In biology, the memory process of flies and mice is similar to that of humans at the molecular level. Therefore, scientists believe that this study will help to develop drugs to delay the onset of Alzheimer's disease.

Biologists have been able to prove that spermidine, an endogenous substance, can trigger autophagy in cells. On June 5438- 10, 2009, Professor Madeo published a related paper "Spermidine-induced autophagy promotes longevity" in Nature Cell Biology. Now, further research by the joint research team shows that by feeding spermidine to Drosophila melanogaster, the amount of protein condensation in Drosophila melanogaster's brain is obviously reduced, and the memory ability of Drosophila melanogaster is also improved. This result is verified by measurement, because fruit flies remember what they have learned through the study of classical Pavlov conditioned reflex, and adjust their future behavior accordingly.

Scientists say that research applied to patients is the next goal of the joint research team. The memory ability of human beings begins to weaken around the age of 50. This decay will accelerate with age. Due to the increase of life expectancy, dementia induced by age factors has increased significantly. However, the concentration of spermidine in Drosophila melanogaster and human also decreased with age. If spermidine supplementation can delay the onset of dementia, it will mean an important breakthrough for patients and society. The effect of spermidine on protein with different molecular weight is different. With the extension of spermidine treatment time, some bands with large molecular weight are obviously enhanced, indicating that protein may be synthesized, but the percentage of protein in the total protein is very small, and the effect on protein with medium molecular weight and small molecular weight is not obvious. The main protein remains basically unchanged within 72 hours of treatment. It can be inferred from these results that protein with different molecular weights may have different functions in the senescence process, and some protein with large molecular weight may play a key role in controlling the senescence process of leaves. Once these protein begin to degrade, aging is inevitable. Controlling the degradation of these protein can delay the aging process. The reason of spermidine delaying aging may be to promote the synthesis of these protein or prevent its degradation.