A book on renal biopsy pathology

Basic information

Pathology of renal biopsy (first edition)

Author: Zou

Press: Peking University Medical Press

Release date: 2006- 1- 1

ISBN: 97878 107 18578

Page count: 263

Words: 435000

Format: 16

Pricing: 198.00 yuan

Paper: coated paper

Packaging: hardcover

brief Introduction of the content

Renal biopsy is an important part of kidney disease and an important branch of pathology. At present, the pathological diagnosis of renal biopsy has become an important reference for nephrologists to diagnose, treat and judge the prognosis of patients with renal disease. There are many monographs on pathological diagnosis of renal biopsy abroad, but few in China, which brings inconvenience to clinicians and pathologists. It is the original intention of this paper to write a monograph on pathological examination of renal biopsy with China characteristics in time to help clinicians and pathologists of renal diseases in China understand and carry out this work.

It has been nearly 50 years since Peking University Institute of Nephrology and the Department of Nephrology of the First Hospital of Peking University carried out renal biopsy and pathological examination. In recent years, there have been more than 1000 cases every year, with many cases and various diseases. Over the years, a group of successful renal biopsy pathologists and technicians have been trained, and a large number of talents in this field have also been trained for all parts of the country. The materials in this book are mainly renal biopsy cases filed by Peking University Institute of Nephrology, and have also been obtained from the Department of Pathology of Peking University, the Department of Nephrology of China-Japan Friendship Hospital of Ministry of Health and Peking University.

Based on pathomorphology, this book has collected more than 600 precious pathological pictures, some of which are specially allowed and presented by relevant authors and professors, and they are all precious clinical materials. This book focuses on the pathological changes of renal diseases, differential diagnosis in pathological diagnosis, thinking methods and pathological techniques in pathological diagnosis of renal biopsy. * * * is divided into 19 chapters, which answers common questions in renal biopsy and won the prize-winning book of "Three Hundred" original publishing project.

Library catalogue

The first chapter is the significance and history of renal biopsy in renal diseases.

Chapter II Embryogenesis, Anatomy and Histology of Kidney

Section 1 Embryonic Development of Kidney

Section 2 Renal Anatomy

Section III Renal Histology

I. Nephron

Second, the glomerulus

Third, renal tubules

Four, renal interstitial

Five, renal calices, renal pelvis and ureter

Six, renal blood vessels

Seven, renal lymphatic vessels

Eight, renal nerve

The third chapter introduces the treatment of living kidney transplantation specimens and the method of pathological final examination.

First, optical microscopy.

Second, immunopathological examination

Third, the electron microscope examination

Fourthly, in situ hybridization.

Verb (abbreviation of verb) in situ PCR

The fourth chapter is the common pathological changes of renal biopsy.

Section 1 Common pathological changes of glomerulus

First, the common pathological changes of renal capsule

Second, podocytes (renal capsule visceral cells) common lesions

Three. Common pathological changes of basement membrane

Four, the common pathological changes of endothelial cells

Verb (abbreviation for verb) Formation of microthrombosis and thrombus-like substances in glomerular capillaries.

Six, glomerular capillary dilation, congestion

Seven, the common lesions of mesangial tissue

Eight, glomerular cell infiltration

Nine, glomerular apoptosis

Fibrous necrosis of glomerular capillaries

Xi。 Glomerular sclerosis

Twelve, glomerular accessory organ hypertrophy

Thirteen. Changes of glomerular volume

Common renal tubular lesions in the second quarter

1. Granular degeneration and dropwise degeneration of renal tubular epithelial cells

Secondly, vacuolar degeneration of renal tubular epithelial cells.

Three, renal tubular cast

Four. Renal tubular epithelial cytochrome

V. multinucleated giant cells fused with renal tubular epithelial cells

Pathogenic microorganisms of intransitive verbs and inclusion bodies of renal tubular epithelial cells

Seven, acute tubulointerstitial inflammation

Renal tubular epithelial cells brush off.

Nine, acute tubular necrosis

X. regeneration of renal tubular epithelial cells

Eleven, renal tubular atrophy

Twelve, compensatory hypertrophy of renal tubules

Section 3 Common Renal Interstitial Lesions

First, renal edema

Two. Infiltration of inflammatory cells in renal interstitium

Three. Renal interstitial granuloma

Four, renal interstitial tumor cell infiltration

Five, renal interstitial fibrosis

……

Chapter V Pathological Classification of Kidney Diseases

Primary Glomerular Disease Chapter I Kang

Chapter VII Secondary Glomerulonephritis

Chapter II Kidney Diseases Caused by Abnormal Metabolism

Chapter IX Abnormal Globulinemia Nephropathy

Chapter 10 Renal Tubular Diseases

Chapter II XI Renal Interstitial Diseases

Chapter XII Renal Tubular Interstitial Nephropathy

Chapter 13 Renal Injury of Vascular Diseases

Chapter XIV Congenital and Hereditary Kidney Diseases

Chapter 15 Other Kidney Diseases

Chapter XVI Pathology of Renal Transplantation

Chapter XVII Renal Damage Caused by Other Diseases

Chapter 10 Problems needing attention and basic analysis methods in pathological diagnosis of renal biopsy

Chapter 19 Basic information on the method of making pathological specimens of renal biopsy

Pathology of renal biopsy (second edition)

Author: Zou

Press: Peking University Medical Press

Release date: September 2009-1

ISBN:97878 1 1 167924

Page count: 306

Words: 6 15000

Format: 16

Pricing: 228.00 yuan

Paper: coated paper

Packaging: hardcover

brief Introduction of the content

Renal biopsy pathology mainly discusses the histopathological manifestations and diagnostic points of percutaneous renal biopsy. On the basis of the first edition, the following supplements and revisions have been made: ① On the basis of the third edition of Kidney Diseases edited by Professor Wang Haiyan, we have a deeper understanding of the etiology and pathogenesis of various kidney diseases, and also made an appropriate introduction to this book. ② The author collected a large number of representative data and pictures, and successfully carried out some practical new pathological methods of renal biopsy, which enriched the new edition, such as the pathological characteristics of some hereditary and metabolic renal diseases. (3) Nephrologists and renal biopsy pathologists are required to have a holistic concept when diagnosing renal diseases. For this reason, this book makes a great supplement to chapter 17. ④ Chapter 18 "Pathological diagnosis of renal biopsy" has been greatly revised. ⑤ Chapter 19 increased the close cooperation between clinicians and pathologists, and selected and supplemented more than 200 pictures.

Library catalogue

The first chapter is the significance and history of pathological examination of renal biopsy in renal diseases.

Chapter II Embryogenesis, Anatomy and Histology of Kidney

Section 1 Embryonic Development of Kidney

Section 2 Renal Anatomy

Section III Renal Histology

I. Nephron

Second, the glomerulus

Third, renal tubules

Four, renal interstitial

Five, renal calices, renal pelvis and ureter

Six, renal blood vessels

Seven, renal lymphatic vessels

Eight, renal nerve

Chapter III Treatment of Renal Biopsy Specimens and Pathological Examination Methods

First, optical microscopy.

Second, immunopathological examination

Third, the electron microscope examination

Four, * * * focused laser scanning microscope inspection

5. In situ mixing method

Six, in situ PCR

Seven, other methods of molecular pathological research using renal biopsy specimens.

Chapter IV Common Lesions of Renal Biopsy

Section 1 Common pathological changes of glomerulus

First, the common pathological changes of renal capsule

Second, podocytes (renal capsule visceral cells) common lesions

Three. Common pathological changes of basement membrane

Four, the common pathological changes of endothelial cells

Verb (abbreviation for verb) Formation of microthrombosis and thrombus-like substances in glomerular capillaries.

Six, glomerular capillary dilation, congestion

Seven, the common lesions of mesangial tissue

Eight, glomerular cell infiltration

Nine, glomerular apoptosis

Fibrous necrosis of glomerular capillaries

Xi。 Glomerular sclerosis

Twelve, glomerular accessory organ hypertrophy

Thirteen. Changes of glomerular volume

Fourteen, immature glomeruli

Common renal tubular lesions in the second quarter

1. Granular degeneration and dropwise degeneration of renal tubular epithelial cells

Secondly, vacuolar degeneration of renal tubular epithelial cells.

Three, renal tubular cast

Four. Renal tubular epithelial cytochrome

V. multinucleated giant cells fused with renal tubular epithelial cells

Pathogenic microorganisms of intransitive verbs and inclusion bodies of renal tubular epithelial cells

Seven, acute tubulointerstitial inflammation

Renal tubular epithelial cells brush off.

Nine, acute tubular necrosis

X. regeneration of renal tubular epithelial cells

Eleven, renal tubular atrophy

Twelve, compensatory hypertrophy of renal tubules

Section 3 Common Renal Interstitial Lesions

First, renal interstitial edema

Two. Infiltration of inflammatory cells in renal interstitium

Three. Renal interstitial sarcoplasm

Four, renal interstitial tumor cell infiltration

Five, renal interstitial fibrosis

Common pathological changes of renal blood vessels in the fourth quarter

Atherosclerosis and vitreous degeneration.

Second, arteriolar sclerosis.

Three. Onion-like thickening of arteriole intima

Four. Celluloid necrosis of arterioles

Five, small aneurysm formation

Six, arteriolar thrombosis

Seven, small vein thrombosis

Eight, renal cortical necrosis and renal infarction

Chapter V Pathological Classification of Kidney Diseases

First, the basic principles of pathological classification of renal diseases

Second, the pathological classification of glomerular diseases

Pathological classification of tubulointerstitial diseases

Four, pathological classification of renal vascular diseases

Chapter VI Primary Glomerulonephritis

Section 1 Minimal Pathological Glomerulopathy and Glomerulopathy

Section II Focal Glomerulonephritis

Section III Focal segmental glomerulosclerosis

Section IV Membranous Nephropathy

Section 5 Mesangial proliferative glomerulonephritis

I. IgM nephropathy

Second, Clq nephropathy

C3 sedimentary mesangial proliferative glomerulonephritis

Fourthly, immune oligo-complex mesangial proliferative glomerulopathy.

Section 6 Intracapillary proliferative glomerulonephritis

Section 7 Membranous proliferative glomerulonephritis

Section 8 Crescent glomerulonephritis

Section 9 Hyperplasia, Sclerosis and sclerosing glomerulonephritis

Chapter VII Secondary Glomerulonephritis

Section 1 Lupus nephritis

The second quarter Sjogren's syndrome renal injury

Section III Renal Injury of Mixed Connective Tissue Disease and Overlapping Syndrome

The fourth quarter IgA nephropathy

Section 5 Allergic Purpura Nephritis

Section 6 Hepatic glomerulosclerosis

Section 7 Anti-glomerular basement membrane disease and Goode Pasture syndrome

Section 8 Post-infection Glomerulonephritis

First, hemolytic streptococcus infection

Second, acute bacterial endocarditis

Three. subacute bacterial endocarditis

Fourth, shunt nephritis.

Virus infection and nephropathy

(1) Hepatitis B virus-associated nephritis

(b) Hepatitis C virus-associated nephritis (HCV-associated nephritis)

(3) Nephropathy and glomerulonephritis caused by HIV infection.

Adenovirus infection and nephropathy

(v) Chickenpox-Herpes Zoster Scar Virus infection and nephropathy

(6) parvovirus B 19 infection and nephropathy.

(7) Hantavirus infection and nephropathy

(VIII) EB virus infection and nephropathy

(9) cytomegalovirus infection and nephropathy

(10) polyoma virus infection and nephropathy

(Xi) SARS virus infection and nephropathy

Chapter VIII Kidney Diseases Caused by Abnormal Metabolism

Section 1 Kidney Injury Caused by Diabetes

Section 2 Glomerular Diseases Related to Obesity

Section III Lipoprotein Glomerulopathy

Section 4 Electron Dense Deposition

Section 5 Hyperuricemia Nephropathy and Gouty Kidney

Section 6 Hypercalcemic Nephropathy

Section 7 hyperoxaluria nephropathy

Section 8 Cysteinemia Nephropathy

Section 9 Glycogen Accumulation Disease

Chapter IX Plasma Cell Diseases and Abnormal Globulinemia Nephropathy

Plasma cell disease and monoclonal immunoglobulin deposition nephropathy in section 1.

First, the production and characteristics of immunoglobulin

Globulin produced by plasma cell disease

Third, the classification of plasma cell diseases

Four, monoclonal globulin deposition nephropathy or abnormal proteinemia nephropathy

Verb (abbreviation of verb) Etiology and pathogenesis of abnormal proteinemia nephropathy

Section 2 light chain nephropathy

Section III Heavy Chain Depositional Nephropathy

Section 4 light chain and heavy chain sedimentary nephropathy

Section 5 Macroglobulinemia Nephropathy

Section 6 renal amyloidosis

Section 7 Fibroid Glomerulopathy

Section 8 immune tentacle-like glomerulopathy

Section 9 Cryglobulinemia Nephropathy

Chapter 10 Renal Tubular Diseases

Section 1 Hypertonic Nephropathy

Section 2 Hypokalemic Nephropathy

Section 3 Acute Renal Tubular Necrosis

Section IV Apoptosis in Acute Renal Tubular Necrosis

I. Pathological manifestations

Second, the mechanism and significance of apoptosis in acute tubular necrosis

Section 5 Renal Tubular Atrophy and Compensatory Hypertrophy

Chapter XI Renal Interstitial Diseases

Section 1 pyelonephritis

Reflux nephropathy in the second quarter

Section 3 Xanthogranulomatous pyelonephritis

The fourth quarter renal soft spot disease

Section 5 Renal Tuberculosis

Section 6 Renal sarcoidosis

Section 7 Other granulomatous lesions of the kidney

Section 8 Allergic Interstitial Nephritis

Section 9 Sjogren's syndrome renal injury

Section 10 Renal Injury of Hemorrhagic Fever with Renal Syndrome

Section 1 1 Balkan nephropathy

Chapter XII Renal Tubular Interstitial Nephropathy

Chapter 13 Renal Injury of Vascular Diseases

Renal infarction in the first section

The second section is ischemia. nephropathy

Cholesterol embolism in the third kidney

Section IV Nodular Polyarteritis

Section 5 Thrombotic Microangiopathy

First, the general pathological manifestations

Second, renal diseases characterized by thrombotic microangiopathy.

Hemolytic uremic syndrome (HUS)

(2) Thrombotic thrombocytopenic purpura (TTP)

(3) Malignant hypertension (malignant hypertension and malignant nephrosclerosis)

Systemic sclerosis (systemic sclerosis)

(5) Pregnancy-related thrombotic microangiopathy

(6) Thrombovascular disease related to antiphospholipid antibody (antiphospholipid antibody related TMA)

(7) Malignant tumor and chemotherapy-related thrombotic angiopathy (cancer and chemotherapy-related TMA)

(8) Transplantation-related tumors.

(9) HIV-related microangiopathy

Third, differential diagnosis

Four. Etiology and pathogenesis

Section 6 ANcA-related systemic vasculitis

First, the general pathological manifestations

Two, several kinds of ANCA related systemic vasculitis renal injury

(1) Microscopic polyangiitis (MPA)

(2) Wegener granulomatosis

(3) allergic granulomatous vasculitis or ChurgStrauss syndrome (CSS)

(d) ANCA-associated vasculitis associated with other diseases.

Third, differential diagnosis

Four. Etiology and pathogenesis

Section 7 disseminated intravascular coagulation

Section 8 Primary Hypertension Renal Damage

Section 9 Congenital cyanotic Heart Disease Nephropathy

Section 10 Renal vein thrombosis

Renal cortical necrosis in the 1 1 segment

Section 12 Analgesia of Nephropathy and Renal Nipple Necrosis

Chapter XIV Congenital and Hereditary Kidney Diseases

Section 1 Ahlport's syndrome

Section II Thin Basement Membrane Nephropathy

Section 3 Congenital Nephrotic Syndrome

Section IV Nail-patella syndrome

Section 5 Type Ⅲ Collagen Glomerulopathy

Section VI Fibronectin Glomerulopathy

Section 7 Fabry's disease nephropathy

Section 8 Nephropathy with Lecithin Cholesterol Transacylase Deficiency

Section 9 High Snow Disease Nephropathy

Section 10 Niemann-Pick nephropathy

Sickle cell nephropathy in section 1 1

Section 12 Urinary depression brown kidney injury

Section 13 renal cystic disease

I. infantile polycystic kidney

Second, adult polycystic kidney disease

Three, renal wasting disease (juvenile nephron renal tuberculosis-medullary cyst disease)

Four, medullary sponge kidney

Verb (abbreviation of verb) acquired renal cyst disease

Six, renal dysplasia

Chapter 15 Other Kidney Diseases

Section 1 Bater's syndrome

Radiation nephritis in the second quarter

Section III Idiopathic Capillary Endotheliopathy

Chapter XVI Pathology of Renal Transplantation

Section 1 Renal Transplantation Rejection

First, the classification of renal transplant rejection

Second, the pathological manifestations

Third, differential diagnosis

Four. Etiology and pathogenesis of renal transplant rejection.

Section 2 Complications in the Treatment of Renal Transplantation Rejection

First, the neurotoxicity of cyclosporine.

Two. Nephrotoxicity of FK506

Third, infection.

4. Lymphproliferative disease after transplantation (PTLD)

Section 3 Recurrence of Renal Transplantation Nephropathy

Section 4 Recurrence of Renal Transplantation Nephropathy

Section 5 Other pathological changes of transplanted kidney

First, acute tubular necrosis

Second, lower urinary tract obstruction.

3. Thrombotic microangiopathy of transplanted kidney

Four. Injury of transplanted kidney caused by ischemia-reperfusion

Section VI Renal Injury Caused by Graft-versus-Host Reaction

Chapter XVII Renal Injury Caused by Other Diseases

Section 1 Malignant Tumor and Nephropathy

First of all, the primary tumor of the kidney

Second, renal metastasis of malignant tumor

(1) Renal metastasis of solid tumor

(2) Lymphatic and hematopoietic tumors of the kidney and renal metastasis.

Three. Immune-mediated renal injury in malignant tumor

Section 2 Castleman's disease and nephropathy

Section III Eosinophilic Lymphgranuloma and Nephropathy

Section 4 Angiolymphoid hyperplasia with eosinophil infiltration and nephropathy

Section 5 Psoriasis and Kidney Disease

Section 6 Thyroid Diseases and Nephropathy

Section 7 Liver Disease and Nephropathy

Section 8 Thymus and Nephropathy

Section 9 Hemodialysis and Nephropathy

Chapter 18 Problems needing attention and basic analysis methods in pathological diagnosis of renal biopsy

Chapter 19 Cooperation between Clinicians and Pathologists in Pathological Diagnosis of Renal Biopsy

First, the requirements for clinicians

Second, the requirements for renal biopsy pathologists

Third, actively carry out clinical and pathological discussion (CPC)

Chapter 20 Methods of Making Pathological Specimens of Renal Biopsy

Section 1 Preparation and Dyeing of Optical Microscope Specimens

I. Fixation

Second, dehydration

Third, transparency.

Fourth, wax dipping.

The verb (short for verb) embeds ...

Limiting intransitive verbs

Seven, dyeing

Section 2 Preparation of Immunofluorescence Test Specimens

I. direct immunofluorescence

Second, indirect immunofluorescence method

Section III Immunofluorescence of Paraffin Sections

Section IV Preparation and Staining of Immunohistochemical Specimens

I. Direct method and indirect method

Second, peroxidase-anti-peroxidase (PAP) method

Three. ABC method

Four, SP or LSAB method

Five, imagine a systematic two-step method

Section 5 Preparation of Test Samples for Transmission Electron Microscope

First, draw materials.

Second, fixed.

Third, dehydration.

Fourth, soak

The verb (short for verb) embeds ...

Limiting intransitive verbs

Section 6 Preparation of Transmission Electron Microscope Specimen of Paraffin-embedded Tissue

Section 7 Preparation of Immunoelectron Microscope Specimen

Index basic information

Renal biopsy pathology

Author: editor-in-chief Guo

Press: Fudan University Press

Release date: August 2007-1

Industrial and commercial bank number: 9787309054552

Version: 1

Pages: 800

Words: 476,000

Page number: 16 Page number

Paper: coated paper

Packaging: hardcover

brief Introduction of the content

This book focuses on the causes, pathogenesis, pathological features (including light microscope, immunofluorescence and electron microscope), diagnosis, differential diagnosis and prognosis of various kidney diseases that occur in human body, especially primary and secondary kidney diseases that are common in clinical kidney diseases. The book provides more than 370 typical pictures of pathological diagnosis collected by the author, which is very helpful for clinical and pathological workers who are committed to studying kidney diseases to learn and master. It is a valuable monograph for teachers and students in medical colleges and clinical pathologists of renal diseases.

Brief introduction of the author

Guo, male, born in 194 1, professor and doctoral supervisor. Since 1993, he has enjoyed the special allowance of the State Council. He used to be the dean of the Basic Hospital of Shanghai Medical University and the director of the Pathology Department. He is good at pathological diagnosis of renal biopsy, in which the research on the mechanism of nephritis and glomerulosclerosis won 7 scientific and technological progress awards from the state, Ministry of Education and Ministry of Health; He presided over the completion of the National, Ministry of Health and Shanghai Scientific Research Fund 12, and has published more than 1 10 papers so far. Editor-in-chief of Practical Surgical Pathology, Pathology, Histopathology Color Atlas and other works, has won the third prize of scientific and technological progress of the Ministry of Health, the second prize of excellent teaching materials of ordinary universities in Shanghai, and the first prize of teaching achievements in Shanghai.

Preface to a book

Renal biopsy pathology is gradually developed with the extensive development and application of clinical renal puncture technology. In the early 1950s, two Danish doctors, Iversen and Bran, used percutaneous nephroscopy for the first time to diagnose renal diseases, which initiated a new era of pathological diagnosis of renal biopsy. For more than half a century, with the development of immunology, immunopathology and electron microscope technology, especially the antibodies used to detect various immunoglobulin, complement, fibrinogen and other components (such as hepatitis B virus antigen, collagen III, etc.) have been commercialized. ) is deposited in renal tissue, and the safety of renal puncture technology is greatly improved. Percutaneous renal puncture technology has become an important means for clinical diagnosis of renal diseases, and the resulting renal biopsy pathology has also become modern pathology.

Since 1980s, renal puncture technique has been adopted and applied by clinicians in China, and the cases of renal puncture have increased year by year, and the pathology of renal biopsy has also developed rapidly. Pathology of Renal Biopsy, edited by Professor Zou from peking university health science center, has also been published. However, compared with developed countries in the world, there is still a big gap in kidney disease in China, which is manifested in the fact that the team of full-time nephrologists has not yet formed, the routine examination of renal puncture tissue is not standardized, and the close connection and cooperation between pathology and clinic is not enough, especially the number of cases of follow-up or repeated biopsy of renal puncture patients is very small, which are all unfavorable factors that hinder the development of kidney disease in China. The author has been engaged in the pathological diagnosis of renal biopsy since 1980s, especially since 1993. By comparing the results of light microscope, immunofluorescence and electron microscope examination of each renal biopsy case, a diagnosis report was issued, which greatly improved the correct rate of pathological diagnosis and the coincidence rate with clinical manifestations. On this basis, the idea of writing this book sprouted. Now, after more than a year of data sorting and writing, a book "Renal Biopsy Pathology" written entirely by domestic data has finally been published. Although I tried my best to do this, due to the rush of time and limited level, there will inevitably be shortcomings or mistakes. Welcome colleagues to criticize and correct me.

This book is the result of years of cooperation between my colleagues and me. Here, I would like to thank my colleague, Deputy Chief Technician Zhang Xiurong, who has completed the pathological examination of each renal biopsy tissue with superb pathological techniques, providing an important technical guarantee for the correct pathological diagnosis. I would also like to thank Professor Zhang Zhigang for completing the compilation of some chapters (Mechanism of Glomerulosclerosis) and the collection and production of pictures, Dr. Ye Liu for completing the production of some color pictures, and colleagues Liu Xueguang, Wu Huijuan, Zhao Zhonghua, Diao, Xu Hui and Li Wenyan for their close cooperation and meticulous production in the aspects of picture collection, tissue section, electron microscope technology and photo development. Without their support and help, it is impossible to fulfill the wish of publishing this book.

outer city wall

Written in August 2007

Library catalogue

Chapter 1 Basic knowledge and pathological examination of kidney

Section 1 Renal Anatomy and Histology

The pathogenesis of nephritis and the basic pathological changes of glomerular inflammation in the second quarter

The mechanism of glomerulosclerosis in the third quarter

Section IV Histopathological Examination of Renal Puncture

Chapter II Primary Glomerulonephritis

Section 1 Mild Pathological Nephritis

Section II Focal Segmental Nephritis

The third quarter diffuse glomerulonephritis