According to foreign media reports, the late trial of a vaccine jointly developed by AstraZeneca and Oxford University was suspended due to serious adverse reactions of volunteers. This COVID-19 vaccine is currently in the third phase of clinical trials. According to the BBC, this vaccine has always been regarded as a strong competitor among dozens of vaccines being developed around the world. The Guardian reported that AstraZeneca and Oxford University suspended important vaccine trials for the second time.

The safety of COVID-19 vaccine has always been the focus of scientists' attention. So far, apart from the Russian vaccine? Sputnik V？ In addition, no COVID-19 vaccine has been successfully marketed. The suspension of COVID-19 vaccine experiment in Oxford University has sounded the alarm for everyone. What is the truth behind everyone's worries?

? Yesterday, STAT, the health news website of the Boston Globe, first reported this incident. The reason for suspending the experiment is that there are serious adverse reactions suspected. AstraZeneca and Oxford University have confirmed the suspension of classes. At present, except Britain, the United States, Brazil, South Africa and other places have suspended clinical trials.

? This is the second time that the UK has suspended this clinical trial. The first pause was in July, and the reason for the pause was the appearance of a volunteer? Penetrating myelitis? This rare disease. However, the volunteer was later diagnosed with an unrelated neurological disease. Therefore, it is uncertain whether the neuroinflammatory reaction in clinical trials is related to the trial itself. Maybe this is an experimental disease, or it may be a congenital disease. So after a series of safety assessments, the experiment started again.

As for the reason for the second pause, AstraZeneca only said that it had observed it. An unexplained disease? . However, according to Nature magazine, it is still uncertain whether this adverse reaction is caused by vaccine, so it is necessary to analyze and evaluate this adverse reaction. According to Nature magazine, the first thing the Committee should do is to check whether the patient receives a vaccine or a placebo.

? At present, according to the vaccine trial design, the proportion of volunteers receiving vaccine trial and placebo trial is about 2: 1. In the third stage of the common vaccine trial, about 20,000 people received the vaccine and 65,438+00,000 people received the placebo, which is a special feature of vaccine research and development. Because the vaccine is aimed at healthy people (other drugs are aimed at patients), the safety requirements of the vaccine are particularly high. This is also the reason why clinical trials need a large number of patients to participate.

? Generally speaking, it is not good news if the same adverse reactions are observed repeatedly in the vaccine group. If it is confirmed that it is just an accident or an unrelated event, we can relax our snacks a little. At present, we need to wait for more information before we can make a judgment.