The team of Professor zhangyan from Liangzhu Laboratory of Zhejiang University Medical College cooperated with the team of Shandong University, Feng and Professor. After three years of joint research, four different types of fatty acids and synthetic agonist TUG89 1 were successfully analyzed at the atomic resolution level to stimulate ω-3 fish oil receptor to form the fine three-dimensional structure of signal transduction complex.
The recognition mode of ω-3 fish oil receptor to unsaturated fatty acids modified by different double bonds was elaborated in detail, and the mechanism that different fatty acids triggered ω-3 fish oil receptor to produce downstream specific signal spectrum was revealed. This achievement was published online in the top international journal Science on March 3rd, Beijing time.
Since it is beneficial to human health, omega-3 fatty acids have naturally become the focus of scientists' research. Miraculously, many other types of fatty acids can cause metabolic diseases such as obesity, diabetes and hypertension, and the difference between Omega-3 fatty acids and them is very subtle.
The "blind box" is waiting to be opened;
In human body, free fatty acids are important energy sources and important signal molecules that regulate many metabolic processes. Fatty acids are divided into saturated fatty acids and unsaturated fatty acids, and also into monounsaturated fatty acids (containing 1 double bonds) and polyunsaturated fatty acids (containing 1 or more double bonds).
Omega-3 fatty acids in fish oil are polyunsaturated fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Scientists have been studying the structure, function and mechanism of omega-3 fatty acids because of their beneficial effects in promoting health and reducing the risk of diseases.