Wu Guanyun, 1924, born on July 27th in Hangzhou, Zhejiang Province, is a biochemist, medical educator, researcher of China Academy of Medical Sciences and professor of Peking Union Medical College.
1943, Wu Guanyun was admitted to the Chemistry Department of St. John's University in Shanghai; 1946 After graduating from the university, he stayed in the school as a teaching assistant in the Department of Chemistry; 1952 was assigned to Shanghai East China Normal University as a lecturer after the adjustment of the department; 1953, from teaching organic chemistry to teaching biochemistry, thus stepping into the field of biochemistry; 1956, joined the China * * * production party; 196 1 officially transferred to the Department of Biochemistry, Institute of Experimental Medicine, China Academy of Medical Sciences; 197 1 year, he came back from Jiangxi may 7th cadre school and went to work in the research institute in Jianyang, Sichuan. 1978 was recommended by the China Academy of Medical Sciences to participate in the cancer delegation organized by the Chinese Medical Association and visited the United States at the invitation of the American Cancer Society; 1987 was appointed by the world health organization as the director of the who cooperative center for community control of genetic diseases (thalassemia); Since 2003, on the basis of her own pension, she has continuously donated nearly 654.38 million yuan to the New Great Wall project to help poor students.
Wu Guanyun's contribution is that a series of new technologies and methods for genetic diagnosis of genetic diseases have been established and popularized for the first time in China, and remarkable social benefits have been achieved. She is also one of the pioneers in studying the principles of TCM treatment at the molecular level.
Chinese name: Wu Guanyun
Nationality: China.
Place of birth: Hangzhou, Zhejiang Province
Date of birth:1July 27, 924
Occupation: teaching and scientific research worker
Graduate school: St. John's University in Shanghai
Masterpiece: Proceedings of medical molecular biology progress, gene diagnosis technology and application.
Character experience
1924 On July 27th, Wu Guanyun was born in Hangzhou, Zhejiang. Shortly after War of Resistance against Japanese Aggression started, that is, three months after her father died, her family took refuge in Shanghai and attended Shanghai Nanping Girls' Middle School.
1943, under the influence of the thought of "saving the country by science" at that time, she entered the chemistry department of St. John's University in Shanghai. She quickly joined the peripheral organizations of the * * * production party and actively participated in various student movements led by the underground party. She was an activist of the student movement.
1946 graduated from winter university and stayed as a teaching assistant in the Department of Chemistry.
1952 department adjustment, she was assigned to teach (lecturer) at East China Normal University in Shanghai.
From 65438 to 0953, due to the need of work, she changed from teaching organic chemistry to teaching biochemistry, so she stepped into the field of biochemistry. With the help of Professor Shen, he entered the Institute of Biochemistry twice and participated in the research of succinate dehydrogenase with high evaluation, thus getting the guidance opportunities of professors Wang Yinglai, Cao and others. The professionalism, rigorous scholarship and enthusiastic teaching of the older generation of researchers in the Institute of Biochemistry have deeply educated and trained her and become a model for her future work.
1956 Comrade Wu Guanyun joined the China * * * Production Party.
196 1 officially transferred to the Department of Biochemistry, Institute of Experimental Medicine, China Academy of Medical Sciences (now the predecessor of Institute of Basic Medicine).
At the end of 1950s, the leaders of China Academy of Medical Sciences deeply felt the importance of nucleic acid research, organized a strong research team, and set up a nucleic acid research group headed by Professor Liang Chih-chuan in the Institute of Experimental Medicine to carry out nucleic acid research. After Wu Guanyun 196 1 was transferred to the Institute of Experimental Medicine, he joined the research team and was responsible for the work of a group. After four years of hard work by all the comrades in the nucleic acid research group, the research work has made a good start and achieved results. This work has also attracted the attention of foreign scholars. In the summary of "Nucleic acid 100", the progress of nucleic acid research in experimental medical research institute was mentioned, and some of the work was well evaluated. In 1978, this work was awarded by the Ministry of Health.
Since the 1960s, she has participated in the rural social education movement and the third-line construction in Sichuan. Ten years of turmoil led to the cessation of all research work, and the members of the research group were scattered around. Wu Guanyun was sent to Jiangxi Yongxiu Health Ministry May 7th Cadre School for labor training. During the five to six years in the four clean-ups, the third line and the May seventh cadre school, she was engaged in manual labor that she had never done before, such as building houses and raising pigs.
197 1 year, she returned to work in the institute that had moved to Jianyang, Sichuan, together with the comrades of the Institute of Basic Medicine of Jiangxi May 7th Cadre School.
65438-0978, recommended by China Academy of Medical Sciences and invited by American Oncology Society, participated in a cancer delegation organized by Chinese Medical Association to visit the United States. This is the second medical delegation after China and the United States resumed academic exchanges after ten years of turmoil. 1In August, 978, the Institute of Basic Medicine moved back to Beijing, and the research conditions were improved. She and the comrades in the group grew up in Sichuan for eight years, and the group added new strength, created good conditions for scientific research, and the work started rapidly.
Since 2003, with her own pension, she has continuously donated nearly 654.38 million yuan to the New Great Wall Project to help poor students.
school achievement
Wu Guanyun's research work mainly contributes to two aspects: prenatal gene diagnosis of genetic diseases and research on the principle of anticancer efficacy of Chinese herbal medicines.
Research and Prevention of Genetic Diseases in China
Wu Guanyun actively pondered and searched for the direction, goal, task and development approach of China's nucleic acid research. Nucleic acid is the carrier of genes, which are closely related to human health and diseases. At that time, a common and high incidence hereditary hemolytic anemia-thalassemia was prevalent in South China. This genetic disease has various clinical manifestations and different degrees of severity, and there is no radical cure. This genetic disease is caused by various mutations (as many as 100) in the genes that constitute the main components of hemoglobin. Wu Guanyun decided to start with prenatal genetic diagnosis of thalassemia, guide and control the birth of severely ill children, and contribute to the prevention and treatment of thalassemia.
There are two kinds of globin: α-globin and β-globin, and the mutations of these two genes cause α -thalassemia and β -thalassemia respectively. Therefore, the team led by Wu Guanyun took the lead in cooperating with six southern units in 1980, and started the research on genetic analysis and early prenatal diagnosis of α -thalassemia. She uses information and cooperation channels at home and abroad to make material and technical preparations. Her laboratory has established a complete set of gene analysis methods, completed the α -globin genotype of 54 patients with HbH disease (a serious and complicated α -thalassemia) in China, provided the characteristics and basic situation of α -thalassemia gene organization in China for the first time, and found a new genotype. 198 1 At the beginning of the year, she cooperated with Guangxi Medical College to establish a method for prenatal gene diagnosis by extracting fetal villi in the first trimester, and successfully completed the prenatal diagnosis of 30 cases of α -thalassemia, creating a precedent for genetic disease gene diagnosis in China. Since then, she has carried out genetic research and prenatal diagnosis of genetic diseases such as β -thalassemia, hemophilia A, Duchenne muscular dystrophy and Barker's syndrome.
It opens up a new field to study the therapeutic principle of Chinese herbal medicine at the molecular level.
Indirubin is an effective component for the treatment of chronic myeloid leukemia, which is separated from Chinese patent medicine Danggui Aloe Pill. At the end of 1970s, the team led by Wu Guanyun studied the effects of indirubin on cells, whole body and various steps of DNA synthesis system in vitro, and proved that its anti-cancer effect was mainly to form a complex with DNA polymerase and template DNA and inhibit DNA synthesis. It is rare for drugs to combine DNA polymerase and DNA at the same time. Indirubin iodide used in chongqing medical Institute further confirmed this result. The work of Wu Guanyun and others not only clarified the molecular mechanism of indirubin against cancer, but also explored a feasible way for the study of anti-cancer mechanism. At the same time, Wu Guanyun's team also studied the therapeutic principle of the anticancer drug harringtonine, which proved that the drug inhibited the synthesis of protein, and its action link obtained new evidence of inhibiting the formation of the first peptide bond before the formation of the first peptide bond. The above work is unique in the study of the mechanism of action of drugs (especially Chinese herbal medicines) in China, which has opened up a new field.
personnel training
Wu Guanyun is diligent in educating people and has trained many accomplished talents. She loves education and has the ability to organize. Soon after she became the director of the teaching and research group of organic chemistry in East China Normal University, she was able to unite all the comrades in the group to make joint efforts to make the original backward teaching and research group of organic chemistry an advanced group. In the teaching work, she insists on preparing lessons carefully, adding new contents and modifying the handouts every time, so the effect is very good and very popular with students.
effectiveness
Wu Guanyun is the oldest donor in the New Great Wall donation project of China Foundation for Poverty Alleviation. Since 2003, with her own pension, she has continuously donated nearly 654.38 million yuan to the New Great Wall Project to help poor students.
Lifelong will:
1. When she was twelve or thirteen years old, she witnessed the Japanese burning, killing and looting in China. She is determined to work hard and contribute to the prosperity of the country.
2. Talent is the foundation of the prosperity of such a big country. The country needs a lot of talents and should contribute to the cultivation of talents.
3. The seedlings growing in hard environment can withstand wind, frost, rain and snow. In case a gifted scholar has difficulty in learning, you should lend him a hand. Since 2003, old Wu Man Guan Yun has continuously donated nearly 654.38 million yuan to the New Great Wall on the basis of his pension. She finds poor students in need of help in various ways and subsidizes them to complete their studies. From the initial Hongzhi class to the new Great Wall project, from donating two students in 2003 to donating three students in 2004, five students in 2005, one student in 2006, and one student in 2007 and 2008, they contributed their strength with their love.
Source of donation
Wu Guanyun's bitter childhood: he lost his father at a young age and grew up with his brother. In the post-War of Resistance against Japanese Aggression era, when I burned and looted Lu, "I thought at that time, why should China people be bullied? The country needs talents, and I am willing to devote my life to the prosperity of the country. "
The growth of college students is also the hope of the country in the future. Supporting poor college students to successfully complete their studies has also fulfilled her lifelong commitment. Over the years, Wu Guanyun has paid attention to poor students through various channels. In 2003, she personally went to Hongzhi Middle School to learn about the poverty alleviation through education in China at that time, and then sponsored 1 middle school students in Hongzhi class. Soon after, she learned about the self-improvement project of poor college students in the New Great Wall of China Foundation for Poverty Alleviation on TV, so she decided to subsidize three poor college students now. In the past three years, the elderly have sponsored 12 poor college students, with a total donation of more than 60,000 yuan.
classic quotations
"The country needs talents, and I am willing to pay for the prosperity of the country for a lifetime!"
"I didn't expect anything in return. I only hope that they can get good grades and have good morality, and they can do their best for the country in the future. "
"As long as I live, funding will not stop. If I am gone, he (Wu Guanyun's husband Lv Rushan) will stick to it. He is healthier than me. Someone has to do it to raise money. There will be several of my children in the future. "
Main work
Some works and papers
(1) Essays on the Progress of Medical Molecular Biology (III) edited by Fang Fu, Yang Shanrong and Shen Yan.
This episode * * * collects the brief introduction of Professor Wu Guanyun, 8 self-selected papers, and the catalogue of more than 100 research papers, and
More than 30 papers and articles written by his colleagues and students can help readers understand the importance of Professor Wu Guanyun.
Require academic performance and rigorous style of study.
(2) Gene cloning strategies of Shen Yan and Wu Guanyun.
(3) Gene diagnosis technology and application, edited by Wu Guanyun and Fang Fu.
(4) Gene Diagnosis edited by Wu Guanyun and Wang Shenwu.
(5) Handbook of Commonly Used Experimental Data in Biochemistry and Molecular Biology edited by Wu Guanyun.
Personality assessment
The first old scientist who initiated prenatal genetic diagnosis is also the oldest donor in the New Great Wall donation project of China Foundation for Poverty Alleviation. As one of the heads of the Department of Biochemistry and Molecular Biology of the Institute of Basic Medical Sciences of China Academy of Medical Sciences for many years, Wu Guanyun has made great contributions to the discipline construction and personnel training of biochemistry and molecular biology, especially in personnel training. She is willing to be a ladder and diligent in educating people. Professor Wu Guanyun is worthy of being a "knowledge pioneer and moral model". During his work, he was a scientist and educator who was active in the forefront of medical science. Join hands with Baishi to love Canada and serve the country.
Wu Guanyun is a very enthusiastic person. She loves this country, this party and her work. She worked hard on the front of science and education with great enthusiasm all her life. Many times by various units as advanced workers, excellent party member.
1982 She shouldered heavy responsibilities in the Department of Biochemistry, and held many positions such as business and administration. She is strict with scientific research and works hard; In administration and party affairs, they can set an example and dare to grasp and manage. Therefore, all the work has achieved good results, won unanimous praise from colleagues, and was rated as an excellent party member of Academy of Medical Sciences and Foundation Institute.
In scientific research, her outstanding contributions are as follows: first, a series of new methods and technologies for genetic diagnosis of common and severe genetic diseases have been established in China, and they have been popularized and applied, which has achieved remarkable social benefits, opened a new chapter in the research and prevention of genetic diseases in China and brought good news to improve people's health. Therefore, she won many national and ministerial awards and was appointed as the director of the Community Cooperation Center for Genetic Disease Prevention and Control of the World Health Organization. Wu Guanyun is also one of the pioneers in studying the principle of TCM treatment from the molecular level, and has made many achievements.