The successful separation of stem cells has made regenerative medicine a step towards practicality, which is helpful to promote therapeutic research using stem cells and enable doctors to repair, treat and promote the growth of human organs and tissues relatively simply. In addition, because this treatment method uses its own cells, the patient will not have allograft rejection. In 2002, Professor Shimizu Hiroshi from Keio University of Engineering and Technology, together with the Japan Association for Science and Technology, built the fastest electric vehicle in the world, which can run at a speed higher than 365,438+00 kilometers per hour. Car KAZ is 6.7m long and1.95m wide. * * * has eight wheels and a 600-horsepower engine. It is powered by 84 lithium batteries, and the zero acceleration to 65,438+000 km/h takes only 7 seconds. In 2003, Masamasa Ueda of Keio University School of Medicine in Japan developed a new vector suitable for gene therapy of hepatitis B virus, which is easy to combine with liver cells and can effectively improve the therapeutic effect of liver diseases. This vector is developed by using an antigen called HBs on the surface of hepatitis B virus, which can transfer specific genes into cells. The researchers put HBs antigen and therapeutic gene into yeast at the same time, and made particles with many HBs antigens on the surface and a diameter of 100 to 200 nanometers. In order to capture the particle's whereabouts in the body, they injected the fluorescent protein gene into the particle, and then injected the particle into two kinds of experimental mice implanted with human liver cancer cells and colorectal cancer cells. As a result, therapeutic genes were found in liver cancer cells, but not in colorectal cancer cells. In addition, in the experiment of using the new carrier to carry the compound, the compound only reached the liver. Therefore, experts believe that this vector is easy to combine with liver cells and has the function of delivering drugs for treating liver diseases. In 2005, a research group of Keio Medical University developed a peptide compound called "BAXIP", which can be used to develop therapeutic drugs for neurodegenerative diseases such as Parkinson's disease. The substance developed by the research team has inhibitory effect on protein, which promotes cell death, and it has been confirmed by animal experiments that it can prevent cell death. Patients with neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, gradually die of cells, and their neurological function is impaired, which leads to the onset and deterioration of diseases. The cause of cell death is not clear, but if cell death can be prevented, the onset and deterioration of the disease can be suppressed. Similarly, this substance may also have therapeutic effects on ischemic diseases such as myocardial infarction and cerebral ischemia related to cell death. 20 10 keio university in Japan said in a press release that cancer cells proliferate faster than normal cells, so the concentration of hundreds of substances in saliva will also change. By comparing the saliva of early cancer patients and normal people, they found that there were significant differences in the concentrations of 54 amino acids.
The researchers further analyzed these 54 amino acids and found that they can be used to accurately screen a variety of cancers, including oral cancer screening accuracy of 80%, breast cancer of 95% and pancreatic cancer of 99%.
Compared with blood test to screen cancer, saliva test is more convenient and will not increase the burden on the body. Next, the researchers are going to develop saliva analysis instruments with lower cost and simpler operation, so as to reach practical level as soon as possible. 20 10 Biomedical researchers from Keio University and Kyoto University in Japan reported in the new issue of Proceedings of the National Academy of Sciences that they investigated the risk of iPS cells developing into cancer cells for the first time and found a highly safe iPS cell. Then they used the iPS cells for treatment and successfully restored the mobility of mice with spinal cord injury. Astronomy 20 12 The research team of Keio University and National Astronomical Observatory in Japan announced on September 4th that they had discovered a huge spiral gas cloud in the center of the Milky Way galaxy, and named it "molecular cloud of pigtail" according to its shape. This discovery will help to study the center of the Milky Way.
Kong Pengqi, an associate professor at Keio University who led the research team, pointed out: "If a detailed investigation is conducted, it is possible to find out the magnetic field structure at the center of the Milky Way." In 20 13 years, researchers from Keio University and other institutions used skin fibroblasts, and found through "microarray analysis" and "RNA interference method" that only when the expression of "KIAA 1 199" gene was inhibited, the hyaluronic acid decomposition ability of cells would be significantly reduced. However, after the "KIAA 1 199" gene is implanted into cells that cannot decompose hyaluronic acid, the cells can regain the ability to decompose hyaluronic acid. 20/kloc-in June, 2005, the new issue of the online edition of the British journal Nature Communication reported that researchers in the medical department of Keio University found in animal experiments that a drug for treating leukemia "irutinib" can inhibit the deterioration of cerebral infarction and is expected to become a new drug to relieve the sequelae of cerebral infarction. It was found in the experiment that only one kind of multi-protein complex called inflammatory corpuscle was activated after cerebral infarction, which produced cytokines that caused inflammation, and an enzyme called "bruton tyrosine kinase" was needed to activate inflammatory corpuscle. Irutinib, a drug used to treat chronic lymphoblastic leukemia, can inhibit bruton tyrosine kinase. To this end, the researchers trained 50 experimental rats with cerebral infarction and conducted group experiments. The results showed that the symptoms of cerebral infarction in a group of experimental mice injected with "irutinib" were much better than those in a group of experimental mice not injected. Although it has not fully recovered, its motor function has obviously improved. Fukuzawa Yukichi, the founder of Keio University, is a famous Japanese thinker and educator in modern times. He is indifferent by nature and hates politics extremely. He doesn't want to go into politics, nor does he encourage students to go into politics. This pragmatic spirit has become the tradition of Keio University. Today, although Keio University has fewer civil servants than Tokyo University and Waseda University, a number of famous politicians and dignitaries have emerged. In Japanese enterprises, trade, finance and other industrial fields, students of Keio University occupy many important positions and form a group of powerful "Keio Gang".