1, essentially different: the University of California generally refers to the University of California, which is a university administrative system composed of California 10 public universities in the United States and the most influential public university system in the world. The University of Southern California is the oldest top private research university on the west coast of the United States and a world-famous institution of higher learning. One is the university administrative system, and the other is the university.

2. Different geographical locations: the University of California is in California, and the University of Southern California is in Los Angeles, California.

3. The school was founded at different times: the University of California 1868 and the University of Southern California 1880. 1952, "University of California" as an administrative system was separated from "University of California at Berkeley" and was no longer a university.

References:

University of California-Baidu Encyclopedia

University of southern California-Baidu encyclopedia