As far as I know, the Nobel Prize will be awarded to two kinds of research achievements:

One is to provide scientists with research tools or theories, for example, those who win prizes for cryoelectron microscopy can enter books.

Second, the product has great practical value. For example, artemisinin extracted from Tu Youyou can be put on the shelves.

Stone's direction is to analyze protein's structure with Nobel Prize-level tools, which is somewhat similar to that of hospital doctors using nuclear magnetic resonance to detect damage. The first way to win the Nobel Prize is almost impossible, unless the history team changes its research direction from a big perspective.

As for the possibility of the second kind of Nobel Prize, if the history team can analyze protein with great practical significance through cryoelectron microscopy, such as broad-spectrum anti-cancer and targeted AIDS killing, and these analyzed protein are synthesized, which has great advantages in clinical application, and even makes human beings bid farewell to AIDS and cancer forever, then I believe this Nobel Prize will be relatively stable.

A series of achievements of Professor Shi Yigong were published in natureE, which is the work of a very senior technician, the top technician of structural biology, not a scientist. Structural determination based on cryoelectron microscope is not the work direction advocated by Nobel Prize. The technological innovation of cryoelectron microscope itself has nothing to do with him. Professor Shi's work is only about structure, not about mechanism and regulation. The nature of this work determines that no matter how much money is distributed, it is naturally possible, but it is not the result of the Nobel Prize. (Excerpted from @Lydia Yang's answer, invaded and deleted)

Shi's job is to constantly analyze the structure of different protein. For an important protein, as long as its structure is obtained, it is almost certain that a CNS can be published, and many articles have been published. The general process of its work is as follows: ① protein expression and purification; (2) preparing an electron microscope sample; ③ Electron microscope. ④ data processing; ⑤ Send articles.

Protein analysis is only the first step in the research work, and the following work is still very long and challenging. Paying attention to a protein or the same protein family, and figuring out the mechanism of these protein's functions ... These tasks will consume a scientist's life's energy. Stone obviously didn't go back. (Excerpted from an anonymous answer, invaded and deleted)

Therefore, Professor Shi Yigong borrowed more or less the meaning of studying speculation by cryoelectron microscope, which is not the level of the Nobel Prize.

20 17 Nobel Prize in Chemistry was awarded to the developer of cryoelectron microscope. This actually shows the characteristics of the Nobel Prize. First, although there have been awards for medical research and development such as Tu Youyou in recent years, most of them are still in the most basic scientific research field. The second is that the award-winning research should be a directional guide to the whole scientific development, or provide strong methodological support while guiding. The award of small RNA interference technology is the best explanation in this respect, and now the award of cryomicroscope is also the footnote of Nobel Prize.

But this logic has yet to be clarified. As mentioned above, the award-winning research should be a directional guidance or subversive support for the whole scientific development. From this point of view, the research on the history of many CNS(Cell, Nature, Science) papers will not necessarily be "eliminated" by the Nobel Prize, because scientific progress is intertwined. The cryoelectron microscope has promoted the analysis of protein's structure, but the breakthrough and classical analysis of protein's structure may provide important guidance for other studies of the life world and open the door to new research directions. Therefore, it is not valid to deny the possibility of winning the Nobel Prize for the structural analysis research of Shi and protein by winning the prize with frozen electron microscope.

Of course, this does not mean that the analysis and research of protein's structure, even the research of Shi himself and his team, will definitely win the Nobel Prize. As mentioned above, whether you can win the prize depends on whether these studies provide directional guidance for the ongoing and future scientific exploration of mankind. One thing is certain, the publication of CNS itself is not a guarantee of winning the Nobel Prize, or even a necessary condition.

I think China can be awarded the Nobel Prize by a professor in Tsinghua University, while Shihe does whatever he wants, and his work is not systematic. However, Yang Maojun's work system fully analyzed the whole electron transfer chain, overturned the theory that existed in biochemical textbooks for decades, and designed various targeted drugs according to the structure he analyzed. After all, the electron transfer chain is too important.

In fact, this problem should be analyzed from many angles, because cryoelectron microscopy has just won the Nobel Prize. Therefore, in a certain period of time, without outstanding scientific contributions, it is unlikely to be further promoted in the same field.

As we all know, at present, scientific research is in full bloom, and there are actually great breakthroughs in every field, so to some extent, there are actually many candidates for the Nobel Prize, and all of them have the strength to win. Every Nobel Prize is actually a choice among many people who have made outstanding contributions, and it is more a reward for the whole field, not only for individuals, but also for several people to carry forward this field together, so rewarding the whole field is more in line with the essence of the Nobel Prize.

So back to the question itself, there is no doubt about the contribution of history. In particular, he has published many influential articles in top magazines, which has made great contributions to China's scientific research going global and winning international reputation.

However, the winning nature of the Nobel Prize is actually more inclined to basic research. Of course, there are exceptions, so it must be a very practical field. In the field of basic scientific research, this time it was handed over to cryo-electron microscope, and many famous structural analysis of stone was carried out by cryo-electron microscope. He is a user, not an inventor. Only when he has made great achievements and made extremely significant breakthroughs, such as the cure of diseases, will he win the prize.

At present, or in the near future, it is obvious that there will be no obvious breakthrough, so we will reserve this opinion and think that the possibility is not too high, but after a period of time, if more significant achievements are produced, it is still more likely to win the Nobel Prize.

I am engaged in biological research myself. The Nobel Prize is awarded to those groundbreaking researches. In other words, what you have made will become the rice bowls and tools of millions of people in a few years, creating a precedent. For example, any laboratory now uses PCR technology. But the first person I think of is amazing. Shi's team didn't invent the electron microscope, so it won't win the prize for the electron microscope itself. But it is also possible to make an unprecedented discovery in biology through this tool.

There is a possibility that your team will build a cryomicroscope and give you money to help you dig some talents, which will not be much worse than him. He is a migrant worker on the platform, which is far from the innovative ability of most doctors and postdocs. Those who often go on TV, get grades and win prizes are not necessarily really awesome, but amateurs are quiet and easy to be advocated by the media. It's really awesome, often everyone can't see it, and do big things in a down-to-earth manner.

There is no Nobel Prize for Shi's work, is there? Water, water, nature and science are ok, but there should be a long way to go to win the Nobel Prize.

It is absolutely impossible to get it. Now, some important structures in protein are the central nervous system. These works are important, but they are not breakthroughs. Just burn money before measuring genome heat. Now, there are fewer and fewer genomes. A long time ago, protein Group was very popular. . . . . . It's all waves, but it doesn't really contribute much. Cryogenic electron microscopy and crystal diffraction are contributions. In fact, the funds for the following work are all in place, and anyone who wants to do it can do it.

Shi will never win the Nobel Prize. Why? Just like when we were at school, we watched movies with a microscope! Inventing a microscope can win the Nobel Prize, and watching a movie is almost impossible!