1933, graduated from Yi University and entered Shanghai Lei Shide Medical Research Institute as a researcher. Under the guidance of Cai Qiao, he studied the role of liver in glucose metabolism through chronic animal experiments, and revealed the role of liver in maintaining normal blood glucose concentration. Five papers were published in China Journal of Physiology (English version of China Journal of Physiology).
1935- 1937 during their further study in Peking union medical college, under the guidance of Lin kesheng, he and his colleagues conducted a series of studies on the problems existing in the sympathetic nerve center of the medulla oblongata. It is found that there is a decompression area near the fourth ventricle floor of the medulla oblongata, which is the sympathetic inhibition center, and its descending channel is analyzed. Eight papers were completed and published in China Journal of Physiology. Founder of modern blood transfusion in China
Yi robbed China Modern Blood Bank twice during the period of War of Resistance against Japanese Aggression in the early1940s and shortly after the establishment of People's Republic of China (PRC) in the early191950s.
The first time was in 194 1 year, and I was hired by American Medical Aid Association to set up China Blood Bank. At that time, there was no medical technology of blood transfusion in China Iraq has made great efforts to this end. He described this experience in detail in the article "After the establishment of the blood bank of the Military Medical Department":
"/kloc-in the autumn of 0/930, I happened to read the Overseas Chinese Daily in the dormitory of the University of Toronto and saw the notice from the American Association for Aid to China. This is exactly what I want, and it is an application by air mail. Two weeks later, as an intern, Dr. Scott sent a letter to the blood bank of new york Central Hospital. Shi is the host of the hospital blood bank, and also the chairman of the blood bank design Committee of American medical institutions aiding China. ..... I studied in this hospital, and I have the spirit of studying in the past. No matter big or small, I will do detailed investigations and experiments. For blood transfusion, inspection, antisepsis, disinfection and extraction, we should first record the equipment used and the method of equipment configuration, then the operating procedures, and then the experiment. The results of the inspection must be submitted to the technical experts of all departments for review in order to improve. ..... I went to the Third Hair Hospital in the United States (note: BrynMawr Hospital in Philadelphia) to retrain with the pulp retort of Lester Rumija, so that I could dry the plasma at home and save the injury. When I got there, the pocket retort was still in the experimental stage, and it was completed after several transformations, so I had to take a quick look. ..... In my spare time as a plasma distillation intern, I often use my own tools to learn mechanical equipment and maintenance from engineers in our hospital. Yu is designed as a multi-head straw, which can draw out most of the air in the plasma bottle to receive plasma at the same time, and can also be used as a porous flusher, which can flush most burettes used for blood test at the same time. Fortunately, it is successful and users are happy. ..... If a worker wants to do a good job, he must use his tools first. China is a non-scientific and non-industrialized country, and there is no modern equipment and equipment ... The inspection equipment and various machine parts are summarized. Then ask the American Medical Assistance Association for donations. The association is eager to help China, and they are all accurate.
"The more specialized the technical work, the more specific the division of labor and cooperation will be, and it will be unimpeded from the beginning. Blood bank work can be divided into blood transfusion inspection, preparation and disinfection of mechanical affairs and publicity of various departments, which can not be arranged by one or two people. I also ask medical assistance to China to recruit talents who volunteer to serve China blood bank ... They are all willing to sacrifice their existing positions and happiness in the United States and join the war in the motherland. With abundant talents and complete equipment, 1932 set up an experimental blood bank in new york on June 7, with the purpose of cooperating with each other in field practice and testing the durability and universality of various equipment. ..... After the expiration of the experiment in May, since the overseas traffic has been controlled by the military, ... please ask the US government to issue a military travel permit before you can go.
"After returning to China, the six major problems before us are ..., and all kinds of problems can't be solved overnight, and the work of blood transfusion is very urgent, so the blood bank was barely established in Kunming on July 12 of that year. ..... inconvenient transportation is also an obstacle to donating blood to the library. The library then set up a mobile blood donation team and toured around to publicize the collective blood donation movement. ..... Limited blood donation is harmless to health. More than 7000 people have donated blood to our bank, and no one has been hurt by donating blood. This iron fact has broken all the misunderstandings of Chinese people about saving lives by donating blood. "
The second time he rushed to build a blood bank was during the War to Resist US Aggression and Aid Korea. 1952, Yi was appointed as a consultant by the Ministry of Health of the Central Military Commission and went to Shenyang with Shen Kefei and others to build a central blood bank. In a short time, the first large-scale blood bank was established in Shenyang after the founding of the People's Republic of China, and professional training was given to military doctors. I didn't go back to school until the armistice. Yi has been devoted to the study of blood physiology since he worked in a blood bank. He believes that in scientific research, we should be good at combining practical work with theory and combining basic research with applied research. When he was working in new york Blood Bank, he investigated ABO blood group and subtype and M-N Rh type of Chinese in the United States. During my work in Kunming and Changsha, I continued to investigate the distribution of Rh factor in China. According to the survey results, this report is the first report on the distribution of Rh factor in China. From 1946 to 1949, he led his colleagues to study the methods of promoting active immunity, published papers on the determination of serum total protein in urban and rural populations, and the relationship between antibodies and nutrition in protein. It was observed that subcutaneous injection of a small amount of gamma globulin or casein hydrolysate could promote antibody production, which was related to adrenal cortex function, thus providing ideas for exploring and strengthening preventive medicine in active immunity. During the period of 1950 ~ 195 1 year, the influence of parasympathetic antidote on blood drug concentration was observed, and the reviews such as Nutrition and Anemia, Physiological Abnormality of Water Loss and Blood Transfusion to Save the Wounded were written and published in Zhongnan Medical Journal.
Since the mid-1960s, he turned to the study of blood function regulation. He observed that both drug hypnosis and natural sleep can lead to blood dilution, and the deeper the inhibition, the greater the dilution, and when the higher nerve parts are excited by electric shock, the blood concentration appears; It is proved that the fluctuation of blood volume is closely related to the activity process of higher nerve parts. When studying the relationship between blood transfusion pressor response and autonomic nerve activity, it is observed that blood transfusion pressor response participates in the mechanism of nerve reflex, and some of its sensory impulses come from cardiovascular receptors. 1959, he published his translation Neuroregulation of Pituitary.
From 1959 to 1960, he also led the teaching and research departments of biochemistry, pathophysiology, surgery and other disciplines to study plasma substitutes, established a set of experimental methods for animal serum collection, processing and identification, and accumulated a series of internal reference materials.
1962, Yi presided over the establishment of a blood physiology laboratory, and was determined to systematically study leukocyte physiology. On the basis of systematic literature review, the Special Collection of Blood Physiology was edited and published. In this paper, the neurohumoral regulation of peripheral blood leukocyte concentration is studied, and the problems of leukemia and other diseases are tried to be discussed. Since then, the Department of Physiology of Hunan Medical College has become one of the bases of blood physiology research in China. A lot of research work was done by young and middle-aged teachers under the guidance of Yi, but he didn't want to sign his article when he published it.