Professor Wei Toshiba and his academic team's main research directions are biocatalytic engineering and biopharmaceutical engineering. Among them, biocatalysis engineering mainly includes the acquisition of new biocatalysts, the in vitro evolution of enzymes and the development of enzyme functions, the immobilization technology of enzymes or cells and the engineering research of biocatalysis process, with special emphasis on the application of genetic engineering bacteria and their enzymes, and the combination of genetic engineering and biocatalysis engineering to carry out the research of aqueous and non-aqueous biocatalysis processes, including enzymatic transesterification, ester synthesis, oligosaccharide synthesis and chiral synthesis/resolution. Biopharmaceutical engineering mainly includes the cloning and efficient expression of protein/polypeptide drugs and enzymes. Study on stability, culture and fermentation process engineering of genetically engineered bacteria: research on large-scale preparation platform technology of biotechnology drugs.

In the past three years, Professor Wei Toshiba, as the person in charge, has undertaken 22 important national key projects and projects entrusted by enterprises, including 3 "863" projects, 4 natural science funds and 3 national key science and technology projects, with a total funding of more than 50 million yuan. Representative research topics include: technical platform for large-scale preparation of biotechnological drugs (national "863" major project), rolling project of technical platform for large-scale preparation of biotechnological drugs (national "863" major project), directed evolution research of biocatalytic asymmetric synthesis, optimization technology of microbial cell expression product process, biocatalytic chiral drug synthesis platform technology research, experimental and preclinical research of anti-tumor antisense oligonucleotide drugs, and human thyroid hormone genetic engineering (65438).

Professor Wei Toshiba and his research team have published more than 60 academic papers 160 (including more than 60 SCI papers); Cited 37 times; There are more than 60 invention patents and 5 works. Completed 6 provincial and ministerial level project reviews and won 4 provincial and ministerial level awards.

2065438+On June 26th, 2003, Professor Wei Toshiba was employed as an adjunct professor in the School of Life Sciences of Liaocheng University.