From 65438 to 0966, American scientists Zeya and Spitznagel first discovered an antibacterial alkaline polypeptide in polymorphonuclear neutrophils of mammals, mice and guinea pigs, and called it "lysosomal cationic protein". This is what people later called defensin. So far, more than 400 kinds of defensins have been identified.

1985, Dr. Robert Lehrer of the University of California named defensins for the first time, and reported that rabbit defensins MCP- 1 and MCP-2 had direct neutralizing and inactivating effects on influenza virus and herpes simplex virus. The following year, the research team reported that three kinds of α defensins (human α defensins or human neuropeptide (HNP)) in human body have neutralizing effects on influenza virus, cytomegalovirus and vesicular stomatitis virus.

In 2002, Zhang, a Chinese scientist at Allen Diamond AIDS Research Center of Rockefeller University, published an article in Science magazine, reporting that the substance that inhibits HIV replication in human body is α-defensin secreted by T lymphocytes. This discovery provides a new way of thinking and direction for the control and treatment of AIDS, which has aroused widespread concern in the biomedical field.

Since 2003, the core R&D personnel of Hushikang Company have discovered a large number of defensin genes and isolated five natural defensins when constructing the cDNA library of marine organisms such as hippocampus. Since 2007, they have carried out a large number of animal experiments with defensin fermented preparations as feed additives, relying on scientific research and transformation platforms such as the National Engineering Center for Marine Biotechnology in the South China Sea. The results show that the preparation can significantly improve the immunity and disease prevention and resistance of animals.