Henan University now has departments of literature, history and culture, education, philosophy and public administration, law, journalism and communication, foreign languages, economy, business, mathematics and statistics, physics and electronics, computer and information engineering, environment and planning, life sciences, chemistry and chemical engineering, civil engineering, art, sports, medicine and pharmacy. Huaihe Clinical College, First Clinical College, International Education College, Software College, Minsheng College, International Chinese Language College, Eurasian International College, Miami College, Distance and Continuing Education College, University Foreign Language Teaching Department, Public Sports Teaching and Research Section and other colleges (departments).

There are 97 undergraduate majors, 43 first-class disciplines authorized by master's degree, 24 first-class disciplines authorized by master's degree, 20 first-class disciplines authorized by doctor's degree, and 15 post-doctoral research stations.