Taking folic acid as the target, FA, PEG and DSPE*** were linked at the valence of * * * to prepare folic acid-mediated long-circulating silybin solid lipid nanoparticles (FA-SIL-SLN). The prescription and preparation process of emulsion-ultrasonic dispersion method were optimized, and the quality, in vitro release behavior, in vivo kinetics, in vivo distribution and lung targeting of the drug delivery system were studied. MTT assay was used to detect its effect on A549 cells, and flow cytometry was used to detect its effect.
Yu Lian, director of the Pharmacy Teaching and Research Section of the School of Chemistry and Pharmacy of Jiamusi University, deputy director of the Pharmacy Department, secretary of the Party branch of the Pharmacy Department, leader of key disciplines at the school level and tutor of master students, once served as deputy director of the Pharmacy Education Committee of Jiamusi Branch of Heilongjiang Pharmaceutical Society, and successively won excellent teachers, excellent intern teachers, teaching experts in universities and top ten teaching excellence awards. More than 30 papers have been published.
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