1940, Jiang was admitted to Tsinghua University to study in the United States at public expense. 194 1 At the end of the year, he went to the College of Pharmacy of the University of Maryland and studied medicinal chemistry with the promising young pharmaceutical chemist Hatton. Ha Tong thinks that the research of medicinal chemistry should focus on the relationship between the structure and pharmacological action of drugs, which is quite enlightening to Jiang. After he returned to China, based on this idea, he taught medicinal chemistry in the Department of Pharmacy of Peking University Medical College. 1943, after obtaining the master's degree, Jiang went to the Department of Chemistry of the University of Illinois in the United States to study for a doctorate, and studied organic chemistry under the guidance of Adams. At that time, Adams was regarded as a master of American chemistry, and he advocated looking at chemistry as a whole. Inspired by this idea, Jiang read Adams's two books, Organic Synthesis and Organic Reaction, and realized that organic chemistry should pay attention to both the uniqueness and particularity of groups. It not only emphasizes the regularity of * * *, but also considers the exceptions; Different molecules and groups should be considered together. Organic molecules are interrelated whole, not isolated individuals. This requires efforts to express the * * * properties of compounds, and also requires some means to distinguish the characteristics of compounds. Under the guidance of this idea, Jiang believes that a quantitative method is needed to express the relative activity of molecules or groups. At that time, he wanted to use the popular atomic electronegativity as a measure index, and put forward the idea of using atomic electronegativity to represent group electronegativity, which produced the "induced effect index".
1944 received his Ph.D., was elected as a member of the Honorary Society of American Chemistry, and was awarded the title of American Natural Science Member. At the invitation of pharmaceutical research institute of Lilly Company, he served as a researcher, engaged in the research of pharmaceutical synthesis methods.
1April, 947, Jiang returned to China as a researcher at the Institute of Chemistry, Beiping Research Institute. 1948 was elected as a member of the American Association for the Advancement of Science.
After the founding of New China, the former Institute of Chemistry moved to Shanghai Institute of Organic Chemistry, and Jiang was employed as a professor in the Department of Chemistry of Peking University and the Department of Pharmacy of Beijing Medical College to teach theoretical organic chemistry and advanced medicinal chemistry. While teaching, he conducted research work and devoted all his time and energy to cultivating talents and developing scientific undertakings. From 1950 to 1956, five classes of students and two groups of graduate students from the Department of Chemistry of Peking University and ten classes of students from the Department of Pharmacy of Beijing Medical College were trained. On the basis of summarizing a large number of literatures, he creatively combined the molecular structure of drugs with pharmacological effects and expounded the principles of designing and selecting drugs from the perspective of organic structure theory. This was unique in the teaching of medicinal chemistry at that time. He not only trained a group of pharmaceutical chemists for New China, but also completed the 640,000-word masterpiece Advanced Pharmaceutical Chemistry (1958 Science Press), which has a considerable influence in the pharmaceutical field and is still a must-read reference book for pharmaceutical college students and workers in relevant production units. In addition to teaching students professional knowledge, he also talks about thinking methods to let students know the development trend of the subject. In scientific research, he found a series of relationships between the acid effect of the optical activity of amino compounds and their chemical structures, and found a quantitative relationship between the polarity and optical activity of solvents. He also instructed young and middle-aged teachers to systematically study the synthesis and reaction of quinazoline series heterocyclic compounds. At the same time, entrusted by Zhuang Changgong, director of Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, he set up an organic chemistry group at Peking University Medical College to study the synthesis of chlortetracycline and its derivatives. His training method for young and middle-aged researchers is to take the form of professional group discussion, regularly report academic thoughts, exchange methods for analyzing and solving problems, exchange information, and explore the professional development direction. Realize "academic heart-to-heart". He has always been strict and serious about his work and study. At that time, the young and middle-aged people are now the leaders of institutes and offices, but they still adhere to the style of study of that year.
In addition to teaching and guiding scientific research, Jiang often goes to various places to give lectures or make work reports. From 1953 to 1982, he has been to many institutions of higher learning, such as Northwest University and Nankai University 10, giving lectures at Dalian Institute of Chemical Physics and Shanghai Institute of Organic Chemistry, so that teachers and researchers can understand the development direction of the discipline, advocate the close combination of theory and applied research, and promote the development of scientific research.
Jiang Yu 1952 joined the NLD and served as a member of the Beijing Municipal Committee of the NLD. 1964, and was elected as a deputy to the Third National People's Congress.
In Jiang's view, the quantitative relationship between structural performance has always been the main direction of teaching or scientific research.