Many people have questions: Can cancer be inherited? Look at these examples!
Brother and sister have cancer at the same time and live in the same ward!
On July 6th, Wang Xishan, the surgical director of China Medical Cancer Hospital, received a pair of "special" patients in the outpatient department. These two patients are brothers and sisters, and they are the oldest in the family. Considering that both brother and sister need cancer surgery, Director Wang Xishan specially arranged them in the same ward.
Director Wang Xishan checked the recovery of brother and sister after operation. Photo courtesy of respondents
"My two cousins both died of cancer in their forties. At that time, I was still young and never thought that this disease had something to do with my family. " Wang Zhu (not her real name), the third daughter of this family, told the Health Times reporter that she also found the nodule in 2022 and then had an operation.
However, although the whole family has suffered from cancer many times, the family still feels nothing.
Until the beginning of 2022, eldest brother Chloe Wang (a pseudonym) told his family that he always had "diarrhea" and went to the toilet three or four times a day, but he ate very clean and didn't catch a cold. "What disease will make big brother like this?" The family is puzzled.
By the end of June, Chloe Wang felt that he couldn't wait any longer, so he went to the clinic of the local hospital. During the doctor's diagnosis and treatment, he asked, "Have any relatives in the family ever had intestinal tumors?"
Chloe Wang thought for a moment and told the doctor: Both cousins have had it. Hearing this, the doctor's expression became serious: "Everyone over 40 years old at home should come to the hospital for colonoscopy."
Chloe Wang conveyed the doctor's advice to the four sisters, and the family did not dare to neglect it, so they hurried to the hospital for examination.
The examination results came out soon: Chloe Wang and the second sister Wang Lan were initially diagnosed as colon cancer, the elder sister Wang Mei (pseudonym) was diagnosed with intestinal polyps, and the third sister Wang Zhu and the younger sister Naomi (pseudonym) found no abnormalities for the time being.
"The incidence of colorectal cancer does have family characteristics, but it takes many years for two people in a family to check out cancer. It is rare for brothers and sisters to be diagnosed at the same time, admitted to hospital at the same time, and operated at the same time. " Director Wang Xishan said.
Director Wang Xishan said that the causes of cancer include genetic factors and living habits, and the incidence of hereditary cancer is about 5%. At the same time, by asking a family about their living habits, we know that they eat pickled pickles all the year round, which is also one of the possible causes of cancer.
"Although cancer is not a genetic disease, it has a certain genetic susceptibility. Clinically, parents, brothers and sisters will also suffer from cancer. " Director Wang Xishan told the reporter that there is a family hereditary tumor, mainly because a tumor suppressor gene named APC has a mutation, and there are many polyps in the intestine. After the patients reach their thirties and forties, even if they have no living habits, they can't avoid cancer. There is also a familial hereditary colon cancer with no clinical symptoms. Before the onset, we can't tell whether it is hereditary or non-hereditary colon cancer. According to the family survey, every generation is sick, which is related to the inactivation of nucleic acid repair genes.
Director Wang Xishan suggested that relatives suffering from cancer (especially first-degree relatives) should seek medical attention in time when they have symptoms such as bloody stool, loose stool, change of defecation habits (increased frequency, acute diarrhea, heaviness and so on). ), or anemia, emaciation and weakness. If conditions permit, it is best to have a regular physical examination to facilitate the early detection and treatment of tumors.
The doctor reminds: Some cancers are really hereditary!
In 2022, the Journal of Clinical Medicine of the American Medical Association (JAMA) published a study conducted by scientists from Harbin University in cooperation with Danish and Finnish researchers, explaining the relationship between cancer and heredity. This study started at 1943 and ended at 20 10. * * * 20369 1 The subjects were followed up for 32 years.
The results show that about one third of cancers are caused by genetic factors. Parents will pass on mutated cancer-causing genes to their children, and this congenital mutant gene is almost the same as the acquired mutant gene, which means that cancer is indeed heritable.
In 2022, the Mayo Clinic team published a clinical study on JAMA Oncology, and conducted universal genetic testing on nearly 3,000 cancer patients. It is found that there are 1 hereditary oncogene mutations in every 8 cancer patients, which greatly improves the individualized treatment scheme and survival rate of patients and contributes to cancer prevention and control among family members.
In addition to intestinal cancer, the following six cancers are also easy to inherit!
1.: The risk of having a daughter is 2-3 times higher.
Chen Xiuchun, director of internal medicine of Henan Cancer Hospital, introduced it in Health Times in 2022. It was found that 20%~25% of the patients were familial, of which 55%~60% were hereditary, accounting for 5%~ 10% of the total.
There is a genetic tendency. Generally speaking, mother and daughter are 2-3 times more likely to get sick than other women. Clinically, it is suggested that high-risk groups should check themselves regularly and go to the hospital for physical examination once a year to achieve early detection, early diagnosis and early treatment.
2. Cancer: heredity is mostly caused by gene mutation.
Wu Xiaohua, director of Oncology Department of Cancer Hospital affiliated to Fudan University, introduced in Health Times in 2022 that the main feature of this kind of cancer is familial onset, and the "real murderer" leading to hereditary cancer syndrome is BRCA 1/2 gene mutation.
BRCA 1/2 are two important genes that "inhibit" cell carcinogenesis. Once a mutation occurs, it will open the valve of "inhibiting" cancer, leading to a higher risk of cancer.
Studies have shown that more than 90% of hereditary cancers are caused by BRCA 1/2 gene mutation. For women with cancer or family history, it is suggested that people with BRCA 1/2 gene mutation can undergo preventive excision through genetic testing or effective inheritance to avoid cancer or cancer risk.
In addition, many drugs targeting BRCA 1/2 gene have been put on the market, and it is of great significance to clarify gene mutation for cutting-edge treatment programs.
3. Gastric cancer: an obvious family phenomenon
Chen Suqiong, director of the oncology department of a hospital in Yinchuan, introduced in Health Times in 2022 that gastric cancer is not a genetic disease. But if a person has a family history, the incidence rate is relatively higher than that of people without a family history.
Gastric cancer has obvious familial phenomenon, mainly for two reasons:
The first is genetic susceptibility. It is possible that the family does have the same living habits and the same genetic inheritance, so there may be susceptibility, but it does not necessarily mean that it is a genetic disease.
In addition, a large number of clinical data prove that the offspring of patients with gastric cancer at home do not necessarily suffer from gastric cancer. However, eating habits and the increase of certain carcinogens in the environment that everyone is exposed to will indeed increase the susceptibility of the human body to cancer.
For familial gastric cancer, it is recommended to do regular screening and prevention in advance. If you often have symptoms such as upper abdominal pain, bloating, and unexplained weight loss, you should also go to the hospital as soon as possible for diagnosis.
4. Liver cancer: Children are the main prevention targets.
Wang Qian, deputy chief physician of hepatobiliary and pancreatic surgery in Henan Cancer Hospital, introduced in an article in Health Times in 2022 that if parents are diagnosed with liver cancer, their children are the primary prevention targets, because the vertical spread of hepatitis B can easily lead to the familial tendency of liver cancer. Especially mothers with hepatitis B, their offspring are more likely to suffer from liver cancer.
Liver cancer is mainly related to infection. For example, if one person in a family suffers from hepatitis B or C, other family members will be easily infected. The high-risk group of liver cancer is patients with chronic hepatitis and cirrhosis caused by various reasons. However, as long as patients with hepatitis control in time, actively treat hepatitis and block its development process, liver cancer can be avoided.
If there are hepatitis patients at home, they should be vaccinated regularly. It is suggested to adopt a separate meal system to avoid cross-use of tableware at home and reduce the infection of hepatitis. There are patients with liver cancer at home, and children should have a comprehensive examination, such as liver function, B-ultrasound and so on, regardless of their health.
5. Nasopharyngeal carcinoma: It has obvious familial genetic tendency.
Deng Qinghua, director of tumor radiotherapy department of Hang Cheng Cancer Hospital, introduced in Health Times in 2022 that several people in the same family suffered from nasopharyngeal carcinoma at the same time. Analysis of the reasons, heredity is the basis, but also a factor that can not be ignored. Studies have found that people with a family history of nasopharyngeal carcinoma are 20 to 40 times more likely to get sick than normal people.
One of the items of routine physical examination is to check the nose. Many people think it doesn't matter if they don't do it. In fact, it can screen nasopharyngeal carcinoma. If the location of nasopharyngeal tumor is not particularly hidden, experienced ENT doctors can basically see the lesion when they examine it. At present, EB detection is also an important auxiliary diagnostic method for nasopharyngeal carcinoma. If someone in your family has ever had nasopharyngeal carcinoma, I suggest you go to the hospital for a nasal endoscope and EB examination.
6. Thyroid cancer: There is a certain genetic tendency.
Xia Tingyi, former director of Cancer Hospital of Air Force General Hospital, pointed out in the article 201/Health Times that thyroid cancer has a certain genetic tendency. If there are thyroid cancer patients in immediate family members, other family members should be listed as high-risk groups, and they should go to the hospital for screening as soon as possible. If the condition requires, fine needle aspiration biopsy can be conducted under the guidance of B-ultrasound.
Finally, cancer is indeed hereditary and familial, which is mainly caused by the inheritance of oncogenes and the similar living habits of family members. In daily life, we should be alert to this phenomenon. People who find this situation in their families must pay enough attention to it, do a good job in cancer prevention and screening, and strive to kill cancer in the cradle.
(Original title: Brothers and sisters suffer from cancer and live in the same ward! Expert: These cancers are really hereditary! )
: Health Times
: China search
The above is related to one brother, one sheep and one tiger, and it is about sharing. After reading, my sister is a sheep and my brother is a mouse. I hope this will help everyone!