1934, during the Republic of China, it was reorganized and expanded by Jiangxi provincial government into Jiangxi provincial hospital, and it was determined to be the internship hospital of National Zhongzheng Medical College.
1955 was renamed as the Affiliated Hospital of Jiangxi Medical College;
1958 was changed to the Second Affiliated Hospital of Jiangxi Medical College;
In 2005, Nanchang University merged with Jiangxi Medical College, and the hospital was officially named the Second Affiliated Hospital of Nanchang University.