Long-term chronic alcoholism will not only affect the brain, but alcohol is a neurotrophic substance with neurotoxic effect, which can directly kill brain cells and make them dissolve, disappear and decrease.

Long-term drinkers will have faster brain cell death and more severe brain atrophy. With the decrease of cerebral blood flow, the glucose metabolism rate in the brain and the activity of brain nerve cells decrease, and the brain function decreases accordingly. Alcohol can also inhibit protein synthesis. The less patients with chronic alcoholism eat, the less protein they consume, the more obvious protein deficiency, and the more serious brain function and brain atrophy.