Nucleic acid detection of novel coronavirus's disease alone can produce results of about 30 minutes. In the process of nucleic acid detection, samples need to be collected first, then stored and transported. It takes about 6 hours from the collection of samples to the results, and sometimes the waiting time will be longer. When conducting nucleic acid detection, the sample should be treated first. Many throat swab samples need to be checked and classified after they are sent to the laboratory. This connection will take about 3-4 hours.

After extracting nucleic acid, polymerase chain reaction was carried out. This process also takes 80~ 120 minutes. After the completion of polymerase chain reaction, evaluate the results and then publish the report. Some difficult samples may need to be repeatedly tested or re-collected for testing, which takes a long time. Professor David Moses and Professor Zhang Ying from the Institute of Medicine, Zhongnan Hospital, Wuhan University, Center for Immunology and Metabolism, Ministry of Education, developed a new rapid nucleic acid detection method SPAMC, which has the characteristics of high sensitivity, high specificity and simple operation.

Researchers tested 204 kinds of throat swab samples with COVID-19's disease method, and the accuracy rate reached 94.2% in real samples in COVID-19. There were no false positive cases. It only takes 20 minutes to detect the virus, and the detection results can be observed by portable ultraviolet light or blue light, which greatly improves the convenience of detection. This system is a new rapid molecular diagnosis technology based on the combination of nucleic acid hybridization and immunofluorescence capture, namely hybridization capture immunofluorescence analysis. The average sample detection time is 45 minutes, and one instrument can detect up to 60 samples in one hour.

One-step rapid detection of pathogen nucleic acid. No nucleic acid extraction and purification, no PCR amplification; By treating the solution, the pathogen is directly cut and the target nucleic acid is released. The target nucleic acid and probe form DNA/RNA hybridization. The fluorescent particles recognize the fluorescent signal of DNA/RNA hybridization and realize the qualitative judgment of the target nucleic acid in the sample. The toolkit can be stored and transported at room temperature to minimize dependence on cold chain logistics. This technology performs well in the timeliness of sample detection, the availability of technical platform, the convenience of inspection and detection, and the adaptability of reagent environment.