The role of angelica dahurica
1. Beauty efficacy: expelling wind, relieving exterior syndrome, dispelling cold and relieving pain, removing dampness and dredging orifices, reducing swelling and discharging pus. It can improve human microcirculation, promote skin metabolism, eliminate excessive pigment accumulation in tissues, eliminate facial scars, and treat skin scabies. Shennong's Herbal Classic points out that Angelica dahurica:? Long skin. Moisturizes color and can be used as facial fat. ? Is it? Money into the cotton paper mill? Or the secret recipe of Empress Dowager Cixi in Yan Palace? Yu Rongsan? Angelica dahurica is the main medicine for making facial fat. It's called removing facial dark spots. Modern medicine has proved that Angelica dahurica has a certain curative effect on acne, blackheads and acne, and has a unique curative effect on whitening and removing spots, improving microcirculation and delaying skin aging.
2. Antipyretic, analgesic and anti-inflammatory effects: Angelica dahurica or Angelica dahurica decoction (15g (crude drug) /kg) has obvious antipyretic effect on rabbits with fever caused by subcutaneous injection of peptone, and its effect is better than that of aspirin (0. 1g/kg). The inhibitory rates of Angelica dahurica decoction, ether extract and water extract (8g (crude drug) /kg) on acetic acid writhing in mice were respectively. The hot plate test in mice also significantly improved the pain. The decoction of Radix Angelicae Dahuricae (4g (crude drug) /kg) can also significantly inhibit ear inflammation induced by xylene in mice. It is also reported that Angelica dahurica has no inhibitory effect on the pain caused by tail pinching and scalding.
3. Cardiovascular effect: The ether-soluble components extracted from Radix Angelicae Dahuricae and Radix Angelicae Dahuricae have obvious dilating effect on blood vessels of retired rabbits, while the water-soluble components of Radix Angelicae Dahuricae have vasoconstricting effect. The coumarin component of Angelica dahurica can dilate coronary vessels, and isoimperatorin can reduce the contractility of isolated frog hearts.
4. Effect on smooth muscle: The ether-soluble and water-soluble components of Angelica dahurica or Angelica dahurica can inhibit the spontaneous movement of isolated rabbit small intestine; Ether-soluble components can also resist the tension contraction caused by physostigmine, neostigmine and barium chloride, and water-soluble components can also resist the tension contraction caused by barium chloride. Isoimperatorin has spasmolytic effect on rabbit ileum, and can enhance the contractility of rabbit uterus and the tension of earthworm muscle.
5. Effect on fat metabolism: the concentration is 5? Incubation with isolated rat adipocytes at 10-4mol/L has no obvious effect on fat metabolism, but it can enhance the lipolysis induced by adrenaline and ACTH, inhibit the conversion of glucose to fat induced by insulin, indirectly promote lipolysis and inhibit fat synthesis.
6. Photosensitivity: Coumarin compounds such as citronellol, xanthotoxin and isoimperatorin B contained in Radix Angelicae Dahuricae are photosensitive substances. When they enter the body, once they are irradiated by sunlight or ultraviolet rays, they will cause solar dermatitis, redness, increased pigment and thickening of the skin at the irradiated area. The photosensitive activity of xanthotoxin is the strongest, followed by citronellactone, and isoimperatorin B is weak. Photosensitive active substances can be used to treat vitiligo. Isoimperatorin is an effective component in the treatment of psoriasis, which is proved to be effective by clinical erythema measurement.
The furan coumarin compounds contained in it have photosensitivity. When it enters the body, once it is irradiated by sunlight or ultraviolet rays, it can cause solar dermatitis at the irradiated site, making the irradiated site red and swollen, pigment increasing and epidermis thickening. It can be used to treat psoriasis with photochemical therapy.
7. Antibacterial effect: Angelica dahurica has inhibitory effects on Escherichia coli, Shigella sonnei and Shigella flexneri, Proteus, typhoid and paratyphoid bacilli, Pseudomonas aeruginosa, Vibrio cholerae, some Gram-positive bacteria and human mycobacteria. Trichophyton floccosum, Trichophyton gypsum and Trichophyton folliculosum were inhibited in vitro, and 1: 3 water immersion inhibited Odouan bud.
8. Anti-inflammatory effect: Injecting Radix Angelicae Dahuricae or Radix Angelicae Dahuricae decoction (lg is equivalent to crude drug lg)4g/kg to mice can obviously inhibit ear inflammation caused by xylene (P < 0.0 1).
9. Antipyretic and analgesic effects: The animal model of high fever caused by subcutaneous injection of peptone into the back of white rabbits, namely, Radix Angelicae Dahuricae 65438±0g or Radix Angelicae Dahuricae decoction 65438±05g/kg, has obvious antipyretic effects. 8g/kg of Radix Angelicae Dahuricae or 8g/kg of Radix Angelicae Dahuricae decoction can significantly reduce the writhing times of mice induced by intraperitoneal injection of 1% acetic acid (0.l/kg), and its effect is similar to that of aminopyrine 8mg/kg, P
10. Spasmodic effect: bergamot lactone, xanthotoxin and isoimperatorin B contained in it have obvious spasmolytic effect on rabbit ileum. Isoimperatorin can also increase the contractility of rabbit uterus and the tension of earthworm muscle. Scopolamine has spasmolytic effect on uterine spasm induced by estrogen or barium chloride in rats in vivo or in vitro, and its ED50 is 0.09mg/kg.
1 1. Effects on cardiovascular system: Isoimperatorin and olaquindox contained in this product can reduce the blood pressure of cats, and the arterial pressure of 1.5h is reduced by 50% at 50mg/kg. The copolymer of isoimperatorin and N- vinylpyrrolidone can prolong the time of reducing arterial pressure of cats by 5 5- 10/. It can also reduce the contractility of isolated frog heart.
12. Antibacterial effect: Radix Angelicae Dahuricae decoction has inhibitory effect on Escherichia coli, Shigella dysenteriae, Proteus, Typhoid Bacillus, Paratyphoid Bacillus, Pseudomonas aeruginosa, Vibrio cholerae and human tuberculosis. Imperatorin contained in this product has antibacterial effect on 1 1 strain in vitro. Imperatorin also has antibacterial effect. Xanthotoxin; The MIC of human mycobacterium tuberculosis H37RV is 100mcg/ml. The aqueous solution also has a certain inhibitory effect on pathogenic fungi such as Ralstonia solanacearum.
13. Anti-cancer effect: isoimperatorin and autogenous gel have cytotoxic effect on Hela cells. Isoimperatorin ED50 100? Microgram/ml.
14. Anti-radiation effect: The methanol extract of Angelica dahurica 1g/kg was injected intraperitoneally 5 minutes before X-ray irradiation, which had protective effect on the skin damage of mice.
15. Other effects: Angelica dahurica has central excitatory effect. A small amount of angelica dahurica toxin can excite the respiratory center, vasomotor center, vagus nerve center and spinal cord of medulla oblongata, make breathing excited, raise blood pressure, slow heart rate and cause salivation; In a large number of cases, it can cause intermittent spasms and then paralysis. Angelica dahurica strongly inhibited 12-0- tetradecanoyl phorbol-13- acetate (TPA, a tumor promoter) from promoting the incorporation of 32P 1 into cultured Hela cells. Its effective components are imperatorin and isoimperatorin at 50? In addition, the methanol extract of Angelica dahurica has protective effect on radiation-induced skin injury in mice by intraperitoneal injection. Effects of angelica dahurica extract on calcium channel blocker receptor and hydroxyl deficiency? The lack of coenzyme A reductase in methylglutaric acid has inhibitory effect, and hexane and ether extracts have inhibitory effect on liver drug metabolizing enzymes, but coral and angelica isolated from them have inhibitory and inductive effects on liver drug metabolizing enzymes.
Toxicity of angelica dahurica
The LD50 of angelica dahurica mice is 42 ~ 45g/kg. The LD50 of Angelica dahurica decoction and Angelica dahurica ether extract were 43g (crude drug) /kg and 54g (crude drug) /kg respectively. The oral LDso of Radix Angelicae Dahuricae photosensitive capsule to mice is 190.6 ~ 2 12.7 times of the human dose. In subacute toxicity test, angelica dahurica photosensitive capsule caused slight changes in renal function, slowed down weight gain, decreased activity and had solid organs. The LD50 of imperatorin in mice was 373mg/kg by intraperitoneal injection, 335mg/kg by intramuscular injection and 65438 060 mg/kg by xanthotoxin rats.
A small amount of angelica dahurica poison has an exciting effect on the motor center, respiratory center, vagus nerve and spinal cord of animals, which can increase blood pressure, slow pulse and deepen breathing, causing salivation and vomiting. A large amount can cause tonic intermittent spasm, and then general paralysis.
Clinical report: This product is effective in treating joint effusion, herpes zoster, psoriasis and other diseases.
Pharmacology (toxicology)
1. The LD50 of Radix Angelicae Dahuricae decoction on mice was 42.88g/kg；; The LD50 of mice fed with ether extract was 53.82g/kg. The LD50 of Angelica dahurica oral decoction on mice was 465438±0.97g/kg；/kg; The LD50 of intramuscular injection of xanthotoxin, imperatorin B and citronellol in rats were 65 438 0 60 mg/kg, 335mg/kg and 945mg/kg respectively.
2. Young rats take imperatorin B daily at a dose of 2.5mg 60/75g for 60 days, which has no obvious effect on the growth of rats, but can cause liver damage. A small amount of angelica dahurica toxin can excite the motor center, respiratory center, vagus nerve and spinal cord of animals, which can cause high blood pressure, slow pulse, deep breathing and vomiting. , and a large number can produce compulsive intermittent convulsions, and then general paralysis.