Before 1994, tylosin used in livestock and poultry breeding in China was imported from abroad, and the price was very high, so it was difficult to be widely used. 1992, Xi Anhengtong Guanghua Pharmaceutical Co., Ltd. (formerly known as Xi Guanghua An Pharmaceutical Factory) introduced the strains and production technology of tylosin from the United States, and built an industrialized tylosin production line in 1994. Its products, tylosin tartrate and tylosin phosphate, have been tested by China Veterinary Drug Monitoring Institute and proved by clinical tests that their physical and chemical properties, antibacterial effects, toxicity, pharmacological effects and prevention and treatment effects on livestock and poultry diseases are similar to those of other companies in the world. Since then, tylosin produced in China has been widely used in animal husbandry to prevent and treat livestock diseases or as feed additives to promote growth. 1. Significant anti-mycoplasma effect.
It has a strong inhibitory effect on mycoplasma such as pleuropneumoniae and is the first choice for mycoplasma infectious diseases in livestock and poultry.
2. Broad spectrum antibacterial
It has a strong inhibitory effect on many Gram-positive (G+) bacteria, some Gram-negative (G-) bacteria, Campylobacter (formerly Vibrio) and spirochete, and also has an anti-coccidiosis effect.
3. Rapid absorption and excretion
No matter oral administration or injection, it can reach the effective bacteriostatic concentration in a short time (10 minute) and keep it for a certain time. After stopping the drug, it will be excreted quickly, and there is almost no residue in the tissue.
4. Good diffusion ability.
It can penetrate into all organs, tissues and body fluids, especially through plasma membrane, blood brain, blood eye and blood testis barrier, which makes tylosin have a wide clinical application prospect.
5. Significantly promote growth.
Feeding tylosin to livestock and poultry continuously at low dose in the growing period can not only prevent diseases, but also significantly promote animal growth, shorten growth cycle and improve feed reward.
6. Particularity of use
Tylosin is a special antibiotic for livestock and poultry, which avoids the cross-resistance problem when antibiotics are shared by people and livestock. Tylosin is a broad-spectrum antibiotic, which has special effect on mycoplasma, strong antibacterial effect on many G+ bacteria, and also has inhibitory effect on some G- bacteria, campylobacter, spirochetes and coccidia.
1. Anti-mycoplasma microorganism
Mycoplasma hyopneumoniae, Mycoplasma gallisepticum, Mycoplasma bovis, Mycoplasma caprae, Mycoplasma bovis, Mycoplasma genitalium, Mycoplasma agalactiae, Mycoplasma arthritis (Mycoplasma arthritis), Mycoplasma hyopneumoniae, Mycoplasma hyopneumoniae and Mycoplasma hyopneumoniae.
2. Anti-gram-positive bacteria
It can resist gram-positive bacteria, such as Staphylococcus, Streptococcus, Corynebacterium, erysipelas and Clostridium.
3. Anti-gram-negative bacteria
Pasteurella, Salmonella, Escherichia coli, Shigella, Klebsiella, Meningococcus, Moraxella bovis, Gram-negative bacteria such as Bordetella bronchiseptica, Mycobacterium, Brucella and Haemophilus parasuis.
4. Campylobacter species
Campylobacter fetus (formerly known as Vibrio fetus) and Campylobacter Escherichia coli (formerly known as Escherichia coli) are Campylobacter fetuses. )
5. Anti-spirochete
Shigella suis, formerly known as treponema suis, Spirogyra anserina and other spirochetes, is resistant to swine dysentery. )
6. Antifungal drugs
It can resist fungi such as Candida and Trichophyton.
7. anticoccidial drugs
Anti-eimeria coccidia, etc. With the increasing production of tylosin in China, the application of this antibiotic in veterinary clinic in China is becoming more and more common. To sum up, it is mainly used to prevent and treat the following livestock and poultry diseases.
1. Mycoplasma disease
It is a remarkable feature of tylosin that it has special effect on mycoplasma, and tylosin has become the first choice for the prevention and treatment of mycoplasma diseases in livestock and poultry. It is mainly used for preventing and treating mycoplasma hyopneumoniae (also known as swine endemic pneumonia, commonly known as swine asthma), mycoplasma hyopneumoniae infection (also known as chronic respiratory diseases in chickens), contagious pleuropneumonia in sheep (also known as mycoplasma hyopneumoniae in sheep), mastitis and arthritis in cattle, agalactia and arthritis in sheep, serositis in pigs, arthritis and synovitis in poultry.
2. Bacterial diseases
Tylosin has a good curative effect on many diseases caused by Gram-positive bacteria and some diseases caused by Gram-negative bacteria. Mainly used for the prevention and treatment of veterinary clinic;
(1) Various purulent diseases caused by Staphylococcus aureus, such as acute and chronic mastitis in cattle and sheep, dermatitis in sheep and septicemia in lambs, dermatitis and abortion in pigs, traumatic infection, abscess and cellulitis in horses, gangrenous dermatitis, septicemia, pneumonitis and arthritis in chickens.
(2) Cow and sheep mastitis caused by streptococcus, swine septicemia, arthritis, swine meningitis, equine adenosis, traumatic infection and cervicitis.
(3) Purulent caseous lymphadenitis (pseudotuberculosis) in sheep caused by Corynebacterium, ulcerative lymphangitis and subcutaneous abscess in horses, nephritis and mastitis in cattle, urinary tract infection in pigs, and clostridial enteritis in pigs caused by Clostridium welchii type C. ..
(4) erysipelas caused by swine erysipelas.
(5) Porcine pneumonia caused by Pasteurella, hemorrhagic septicemia in cattle, cholera in poultry and Pasteurellosis in sheep, horses and rabbits.
(6) Salmonella-induced salmonellosis of livestock and poultry.
(7) Various colibacillosis of livestock and poultry caused by pathogenic Escherichia coli.
(8) Chronic atrophic rhinitis in pigs caused by septicemia in Bordet.
(9) Tuberculosis of cattle, pigs and chickens caused by mycobacteria.
(10) Abortion and infertility caused by Brucella in cattle, sheep and pigs.
(1 1) Abortion and infertility of cattle and sheep caused by Campylobacter fetus (once called Vibrio fetus).
(12) Porcine and chicken enteritis caused by Campylobacter coli (formerly known as Escherichia coli).
3. Treponema disease
Swine dysentery caused by Spirulina Serpentis and avian leptospirosis caused by Borrelia Goose.
4. Anti-coccidiosis drugs
Adding tylosin to feed can prevent chicken coccidiosis. Tylosin has a good growth promoting effect. Rational use of tylosin as feed additive can not only prevent livestock diseases and protect livestock health, but also obviously promote the growth and development of livestock, especially for young livestock and growing livestock, which can improve feed utilization rate, shorten feeding cycle and increase economic benefits of breeding.
Growth promoting effect of 1. on pigs
Yang Libin and others studied the effects of tylosin, olaquindox and Nobida on the performance of growing pigs. The results showed that adding 50mg/kg tylosin tartrate to the diet had the most obvious effect on the growth performance of growing pigs, and the average daily gain (ADG) was 0.69kg, which was significantly higher than that of the control group (P
2. Growth promoting effect on broilers
Zheng Chuntian and others studied the effects of different kinds and doses of tylosin, chlortetracycline and roxithromycin on the performance of broilers. The results showed that the average weight gain of 20mg/kg, 65,438+00 mg/kg tylosin tartrate group and 8.5mg/kg tylosin phosphate group was higher than that of 40mg/kg chlortetracycline group and 50mg/kg roxithromycin group, among which the average weight gain was 65,438+0 ~ 3 weeks and 65,438+08 weeks. 0.05) At the age of 1 ~ 7 weeks, the feed consumption of tylosin tartrate 10mg/kg group was the lowest (2.03∶ 1), followed by tylosin tartrate 20mg/kg group (2.04∶ 1) and tylosin phosphate 8.5 mg/. Considering the economic benefit, environmental protection and hygiene, the suitable addition amount of tylosin tartrate in broiler diet is 10mg/kg. Based on the annual 5 1 10,000 tons of egg feed and meat feed in China, the 10% tylosin premix as an additive needs more than 25,000 tons in China every year.