The first principal of Shanghai Pudong Model Middle School was Wu Xiaozhong, a deputy to the Eighth National People's Congress, a national model worker in the education system, the president of the General Education Branch of the Shanghai Model Worker Association in the education system, an outstanding national principal, a recipient of State Council allowance, a special-grade middle school teacher, and the former principal of Shanghai No.2 Middle School.
The current headmaster is Wei Lan, a senior Chinese teacher.
The head of Chinese teaching and research group is Jiang Yi, the head of mathematics teaching and research group is Chuanbo Zhu, the head of English teaching and research group is Chen Mingye, and the head of physical chemistry teaching and research group is Jin Yan.