Lung cancer is one of the most common malignant tumors in human beings, and it is a refractory disease, which is easy to recur and metastasize. Although a small number of early patients can survive for a long time after active treatment, most patients have lost the opportunity of early active treatment for various reasons. How to make these patients get proper treatment and prolong their life is a difficult problem in the treatment of traditional Chinese and western medicine. Although surgery, radiotherapy and chemotherapy are effective treatment methods, how to make the curative effect better and more lasting; How to alleviate these TCM therapies has great advantages and research value in these aspects. One of the difficulties: early detection and early diagnosis is the key to radical treatment of lung cancer. Early detection (1) attaches importance to the prevention and treatment of precancerous lesions and the prevention of some carcinogenic and cancer-promoting factors. Attention should be paid to patients with chronic pneumonia and tuberculosis. (2) Conduct a general survey of lung cancer and check it as soon as possible to find small, localized and non-metastatic tumor lesions. (3) Educate people to pay attention to precancerous lesions and clinical manifestations of lung cancer, so as to see a doctor in time. (4) Improve the diagnosis level of lung cancer in grass-roots and general hospitals, have a referral system and awareness, and reduce misdiagnosis. 2. Early diagnosis method (1) Repeated sputum exfoliation cytology examination was performed on suspicious objects. (2) Check whether the suspicious object has tumor markers. Such as CEA, serum electrophoresis factors, serum sialic acid determination, neuroendocrine enzymes, mucin 1 antigen and nerve cell adhesion molecules. (3)X-ray chest film, CT and MRI are of great value in the early diagnosis of lung cancer. (4) Fiberoptic bronchoscopy and histopathological examination are of great significance for central lung cancer. (5) Pay attention to the appearance of extrapulmonary symptoms, such as clubbing fingers, anemia or elevated blood cells, hypertrophic osteoarthropathy and recent endocrine disorders. (6) Early diagnosis of lung cancer with monoclonal antibodies is beneficial to the localized diagnosis of lung tumors. (7) Conditional hospitals should check tumor-related oncogenes for suspicious objects. The oncogenes related to lung cancer are: c-eph, L-myc (small cell lung cancer), P2 1 protein, etc. Although some of the above examination methods have certain significance for the early diagnosis of lung cancer, they are rarely specific and should be applied comprehensively. The second difficulty: early detection and re-treatment of postoperative recurrence. Early lung cancer should be reexamined regularly after operation, paying attention to whether the primary focus, lung, brain, bone, liver, kidney, adrenal gland and lymph nodes have recurrence or metastasis. At least once every three months within one year after operation, such as X-ray chest film, high-resolution CT, sputum exfoliative cytology, tumor markers of lung cancer, etc. If there is recurrence, we should accept secondary resection as soon as possible. If the lesion is extensive or metastatic, other methods should be chosen for treatment. No matter which treatment method is chosen, Chinese medicine should be involved, especially for those patients who can't tolerate surgery or radiotherapy and chemotherapy. Practice has proved that the comprehensive anti-cancer treatment of traditional Chinese medicine is superior to the single operation or radiotherapy and chemotherapy for tumor patients, with light side effects and good long-term effect. Traditional Chinese medicine is the best choice for recurrent patients who cannot receive surgery or radiotherapy and chemotherapy. On the basis of disease differentiation combined with syndrome differentiation, better curative effect can be obtained by selecting those Chinese medicines with anticancer effect. The third difficulty: the side effects of western medicine in treating lung cancer directly affect the curative effect. Western medicine does have a certain effect on lung cancer, but the damage to the body caused by its radiotherapy and chemotherapy is a serious problem. He often makes patients give up treatment because they can't stand it, which directly affects the treatment effect-those patients who have undergone surgery or radioactive boils, if they have metastasis or recurrence, are already deficient in qi and blood and weak in viscera function, and then treated with radiotherapy or chemical drugs. Chinese medicine believes that this is the evil of heat and poison. To solve these problems, Chinese medicine has advantages. 1. Traditional Chinese medicine is mainly used for strengthening the body resistance after surgery, radiotherapy and chemotherapy, and promoting the recovery of the body, such as invigorating the spleen and kidney, invigorating the spleen and regulating qi, nourishing yin and clearing heat, supplementing qi and nourishing yin, etc. It can also be supplemented by the method of promoting qi and blood circulation. 2, the use of traditional Chinese medicine to strengthen the body resistance and eliminate pathogens, reduce and treat the side effects of radiotherapy and chemotherapy. Common treatment methods include nourishing yin and clearing heat, invigorating spleen and lung, benefiting qi and nourishing yin, tonifying kidney and marrow, and resisting radiation. 3. Use traditional Chinese medicine to sensitize radiotherapy and chemotherapy to improve the curative effect and prolong the survival time. 4. Traditional Chinese medicine with anticancer effect is used together with radiotherapy and chemotherapy to play a synergistic anticancer role. Difficulty 4: How to solve the problem of multidrug resistance in chemotherapy? Multidrug resistance is one of the main obstacles to the curative effect of tumor chemotherapy. Once tumor cells are resistant to chemotherapy drugs, they will also be resistant to other chemotherapy drugs with different structures and functions. The fundamental problem to solve multidrug resistance is how to reverse+western medicine reversal agent. A lot of research has made great progress. There is a reversal agent of multidrug resistance in Chinese herbal medicine. It has been reported that it can reverse the multidrug resistance of tumor cells in vitro, and has no toxic side effects. At present, traditional Chinese medicines (Radix Astragali, Cordyceps, Ginseng, Fructus Psoraleae, Coicis Semen, Bulbus Fritillariae Cirrhosae, etc. ) those with the function of strengthening the body resistance and strengthening the constitution should choose to carry out clinical and experimental research, and the research focus should be on effective compound prescriptions, such as Liuwei Dihuang Pill, Sijunzi Decoction, Shenqi Pill and Bazhen Decoction. The fifth difficulty: how to resist the metastasis of lung cancer is one of the basic characteristics of lung cancer, which directly affects the curative effect of lung cancer+how to control the metastasis of lung cancer is the difficulty of lung cancer treatment and one of the key topics of current research. How to use traditional Chinese medicine to resist metastasis is a difficult and research hotspot in the treatment of lung cancer. 1. Chinese medicine controls the process of tumor cell metastasis. The use of drugs for promoting blood circulation and removing blood stasis can reduce blood viscosity, increase blood flow rate, reduce the contact and adhesion between tumor cells and blood vessel wall, and may partially block the invasion process of tumor cells and reduce the occurrence of tumor metastasis. For example, ligustrazine contained in Ligusticum Chuanxiong is an effective component for promoting blood circulation and removing blood stasis, which can inhibit platelet aggregation in animal experiments and has anti-tumor metastasis effect. However, it should be noted that not all traditional Chinese medicines for promoting blood circulation and removing blood stasis have the effect of anti-tumor metastasis. For example, animal experiments show that salvia miltiorrhiza, Paeonia lactiflora, Carthamus tinctorius, Angelica sinensis and other traditional Chinese medicines can promote tumor metastasis and should be paid attention to. In addition, the complex components and different varieties of traditional Chinese medicine compound for promoting blood circulation and removing blood stasis directly affect the experimental results, so the research focus should be on the study of single drug and active monomer. 2. Inhibition of tumor angiogenesis is one of the important conditions for tumor proliferation and metastasis. Interfering with tumor angiogenesis can effectively control tumor proliferation and metastasis. Some traditional Chinese medicines (Ginseng, Astragalus, Cordyceps, Codonopsis pilosula, Acanthopanax Senticosus, Lycium barbarum, Epimedium, Kiwifruit) have certain curative effects in this respect, which need further study.