Digital textbooks for compulsory education are developed on the basis of paper textbooks published by People's Education Press, which are rich in three-dimensional resources, interactive and conducive to the development of students' personality. Using this digital textbook for classroom teaching is an important way to integrate chemistry curriculum with information technology. It can create conditions for students to learn chemical knowledge independently and build a knowledge system. The teaching mode of "learning guidance-interactive research" based on digital chemistry textbooks emphasizes that in the process of designing classroom teaching according to teaching objectives, teaching tasks and students' actual situation, the resources in digital textbooks are used to create teaching situations and guide students to learn chemistry. Using digital resources to carry out inquiry activities, let students experience the process of solving problems and constructing knowledge, and finally realize the structure of knowledge, so as to achieve the purpose of cultivating students' core literacy.