In order to achieve the best curative effect, minimize adverse reactions and reduce or delay the emergence of drug resistance, the rational use of antibacterial drugs should follow the following principles:

(1) Strictly grasp the indications.

(2) Grasp the pharmacokinetic characteristics and make a reasonable administration plan.

(3) Avoid drug resistance.

(4) Prevention of adverse drug reactions.

(5) Combined application of antibacterial drugs:

(1) must be clear about the purpose of combined use of antibacterial drugs. The main purpose of combined use of antibacterial drugs is to expand antibacterial spectrum, enhance curative effect, reduce dosage, reduce or avoid side effects, and reduce or delay the emergence of drug-resistant strains. (2) Combination drugs must have clear indications, such as severe infection or mixed infection that is difficult to control with a single drug; For serious infections with unknown etiology and serious life-threatening, combined medication should be given first, and then the medication should be adjusted after diagnosis; Single or long-term drug use is prone to drug-resistant bacterial infection; Infection in parts where drugs are not easy to penetrate; For chronic diseases that need long-term treatment, in order to prevent the emergence of drug-resistant strains, we can consider combining drugs.