The stress response of vaccine refers to the fact that during the process of vaccination, the body produces an immune response, and at the same time, it is also damaged to some extent. Judging from the actual immune effect, under normal circumstances, livestock and poultry often have stress reactions such as rising body temperature, decreasing food intake and increasing mortality after vaccination, which generally return to normal within 3 ~ 15 days after injection, and some will delay for a longer time, thus causing unnecessary economic losses. In order to effectively reduce or avoid the pressure caused by immunization, it is necessary to strengthen the immune awareness of farmers and standardize the operation process. Properly transport and keep vaccines, maintain vaccine equipment and disinfect; Make full preparations before immunization, strictly and correctly follow the immunization procedures and instructions for vaccine use, the vaccine is ready to use, sterile immunization, correct injection, and drinking water control within 2 hours during immunization. Secondly, we should strengthen nutrition and keep pigs healthy. Victoria (500ml to 1000kg water) produced by Hengfengqiang and Jia Lijian (250g to 1000kg water) produced by Dalian Sanyi Company can be used three days before inoculation, which can eliminate or alleviate stress reaction, reduce the economic losses caused by vaccination of many pig farmers and play a positive role in the smooth progress of epidemic prevention work.