Under normal circumstances, the content of IgG in cord blood is 7.6 ~17g/l; The blood IgG content of newborns is 7.0 ~ 14.8g/L, 3 ~ 10.0g/L for 0.5 ~ 6 months, 5 ~ 12g/L for 6 months ~ 2 years, and 5 ~ 13g/L for 2 ~ 6 years. Suffering from chronic liver disease, subacute or chronic infection, connective tissue disease, IgG myeloma, asymptomatic monoclonal IgG disease, etc. , IgG will increase; In the case of hereditary or acquired antibody deficiency, mixed immunodeficiency syndrome, selective IgG deficiency, protein-deficient enteropathy, nephrotic syndrome, myotonic dystrophy, immunosuppressive therapy and so on, IgG reduction will occur.
Under normal IgA, the content of IgA in umbilical cord blood is 0 ~ 50 mg/L; The blood IgA content of newborns is 0 ~ 22 mg/L, 3 ~ 820 mg/L for 0.5 ~ 6 months, 140 ~ 1080 mg/L for 7 months ~ 2 years old, and 230 ~ 1900 mg/L for 2 ~ 6 years old. In the case of chronic liver disease, subacute or chronic infectious diseases (such as tuberculosis and fungal infection), autoimmune diseases (such as SLE and rheumatoid arthritis), cystic fibrosis, familial neutropenia, breast cancer, IgA nephropathy and IgA myeloma, IgA will increase; In the case of hereditary or acquired antibody deficiency, immunodeficiency, selective IgA deficiency, agammaglobulinemia, protein-lost enteropathy, burn, anti-IgA antibody syndrome, immunosuppressive therapy, third trimester of pregnancy and so on, IgA will decrease.
Under normal circumstances, the IgM content in cord blood is 40 ~ 240 mg/L, that in newborns is 50 ~ 300 mg/L, that in 0.5 ~ 6 months is 65,438+050 ~ 65,438+0090mg/L, and that in 6 months ~ 2 years is 430 ~ 2,390mg/L, 2. 6 ~ 12 years old 500 ~ 2600 mg/L, 12 ~ 16 years old 450 ~ 2400 mg/L, adults 400 ~ 3450 mg/L. IgM will increase in cases of intrauterine infection, neonatal TORC H syndrome, chronic or subacute infection, malaria, infectious mononucleosis, mycoplasma pneumoniae, liver disease, connective tissue disease, macroglobulinemia, asymptomatic monoclonal IgM disease, etc. IgM will decrease under the conditions of hereditary or acquired antibody deficiency, mixed immunodeficiency syndrome, selective IgM deficiency, protein deficiency enteropathy, burn, anti-Ig antibody syndrome (mixed cryoglobulinemia), immunosuppression and so on.
Under normal complement C3 and C4, the content of C3(β 1c- globulin) in human blood is 800 ~1550mg/L, and that of C4(β 1e- globulin) is130 ~ 370mg/L. Therefore, the changes of complement level should be observed dynamically in clinic. The decrease of complement content does not necessarily represent immune dysfunction or immune deficiency, because in ischemia, coagulation necrosis and toxic necrosis, tissues can release more proteolytic enzymes, which leads to the decrease of complement hemolytic activity and complement grouping. Generally, the increase of blood complement concentration is found in various inflammatory diseases, obstructive jaundice, acute myocardial infarction, ulcerative colitis, diabetes, acute gout, acute thyroiditis, acute rheumatic fever, dermatomyositis, polymyositis, mixed connective tissue disease, nodular periarteritis, etc.