Coccidiosis is the most common and serious parasitic disease in rabbits. Rabbit coccidiosis can lead to a large number of young rabbits' death, decreased growth rate, decreased resistance, easy to be infected with other diseases, increased production cost and greatly reduced economic benefits, which seriously affects the development of rabbit breeding industry. Therefore, we must pay attention to rabbit coccidiosis and do a good job in its prevention and control. The pathogen of the disease is Eimeria rabbit, and there are 14 species parasitic on rabbits, mainly Eimeria skrjabini, Eimeria perforata, Eimeria gigantea, Eimeria intermedia and Eimeria cecum. Coccidiosis belongs to unicellular protozoa. The trophozoites of coccidia parasitize and reproduce in rabbit intestinal epithelial cells or bile duct epithelial cells, form oocysts and then are discharged with feces, polluting feed, drinking water, utensils, padding and rabbit cages. Rabbit coccidia oocysts developed into invasive oocysts after 2-3 days at 20℃ and 55-75% humidity, which was infectious. Susceptible rabbits are infected after swallowing invasive oocysts. Oocysts have strong resistance to the external environment, and can survive for two months in water and more than one year in wet soil. It is sensitive to temperature and will die in water at 60℃ for 20 minutes. He died in water at 80℃ 10 min; Die in boiling water for 5 minutes. Egg sacs will freeze to death below-15℃, but general chemical disinfectants have weak killing effect on them. According to the parasitic position of coccidiosis, rabbit coccidiosis can be divided into two categories: hepatic coccidiosis is called hepatic coccidiosis when coccidiosis parasitized in hepatic bile duct epithelial cells, and intestinal coccidiosis when coccidiosis parasitized in intestinal epithelial cells. However, it is often these two kinds of mixed infection coccidiosis that are encountered clinically. 1. Epidemic characteristics: the disease can occur all year round, and it often peaks in the rainy season in the south; In the north, it is more common in summer and autumn and is endemic. All kinds of rabbits are susceptible, especially those weaned to 3 months old, and the morbidity and mortality can reach more than 50%. Generally, adult rabbits are infected with worms, and rarely die, but they can excrete oocysts, which is an important source of infection. 2. The incubation period of symptomatic coccidiosis is 2-3 days or longer. The symptoms of hepatic coccidiosis are listlessness, loss of appetite, stagnation of development, emaciation, tenderness and anemia in the liver area, pale mucosa and jaundice in some parts. Enterococcosis is mostly acute, and young rabbits can eat forage before the onset. No abnormal performance, sudden collapse, limb twitching, head back, screaming, and death soon, or temporary recovery, repeating the above symptoms at intervals, and finally death. Chronic intestinal coccidiosis is characterized by physical decline, loss of appetite, abdominal distension, diarrhea, abnormal urination, and wet yellow hair near the tail root. 3. Pathological autopsy showed that the liver of rabbits with hepatic coccidiosis was obviously enlarged, and yellow-white nodules with different sizes and hard texture could be seen on the liver surface, or a large number of vesicular lesions with more translucent liquid could be seen on the liver surface. There are a large number of oocysts in nodules or blisters. The gallbladder is swollen and the bile is sticky. Oocysts can be detected by sampling and smearing them on bile duct and gallbladder mucosa. The pathological changes of intestinal coccidiosis are mainly in the intestine, intestinal wall blood vessel congestion, intestinal cavity gas, intestinal mucosal congestion or bleeding, duodenal dilatation and hypertrophy, mucosal congestion or hemorrhagic inflammation, and small intestine filled with gas and a lot of mucus. Mainly to detect coccidiosis cysts. Acute cases are sometimes invisible to the naked eye, and coccidiosis cysts are also difficult to find. The diagnosis is mainly based on clinical symptoms. In the chronic stage, there are many yellow-white nodules with large needle caps and small purulent necrosis lesions in the intestinal wall, and there are a large number of coccidiosis cysts in the nodules. 4. Prevention: (1) Rabbit huts should be built in sunny and dry places to keep the environment clean and hygienic. Tableware should be cleaned and disinfected frequently, and rabbit cages, especially cage bottom plates, should be disinfected regularly with flame to kill oocysts. ⑶ Drug control was carried out on rabbits weaned to 3 months old, regardless of seasons. Common drugs for preventing coccidiosis and usage: diclazuril broad-spectrum phenylacetonitrile anticoccidial drugs, containing11000 diclazuril premix 100 g per 100 kg feed. Chlorpheniramine 100 kg feed 15g. The above two drugs are used alternately. Diczuli is used for 7-8 months, and then for 4-5 months. The above drugs can also be used for treatment, generally 2~3 times the preventive dose. For the treatment of rabbit coccidiosis,11000 diclazuril premix can be used, and 400-500 grams of feed per100 kg can be mixed evenly, and other feeds and forage grass can be stopped for 2-3 days, and the normal preventive dose can be changed after the disease is controlled. It is worth noting that if rabbits are fed with feed and grass at the same time, the dosage of drugs should be increased in the feed to prevent rabbit coccidiosis, otherwise rabbits will still develop rabbit coccidiosis after using anticoccidial drugs. Excerpted from Selected Papers on Rabbit Breeding and Research by Xue Jiabin.