Today, China has entered the era of digital economy. Digital information is not only high-speed but also real. Using digital technology in the process of college students' mental health education can effectively improve the quality of mental health education and the psychological quality of college students. Therefore, this paper analyzes and discusses the optimization path of college students' mental health education in the digital economy era. With the vigorous development of digital technology, it not only provides a new field of intelligence for college students' mental health, but also poses a new challenge for the reconstruction of self-taught examination. Based on the new background of digital economy era, this paper constructs the content orientation of college students' mental health from the aspects of basic guarantee, internal incentive and external drive, systematically explores the optimization path, and promotes the collaborative interaction between digital economy and science education. With the rapid development of China's economy, the society also puts forward higher requirements for college students' innovation and entrepreneurship in the new period. Especially in the digital economy environment, college students not only need to have the spirit of social practice, but also need to master the knowledge and technology related to the digital economy in order to significantly enhance their competitiveness in the job market. Based on this, this paper is mainly based on expounding the employment status of college students in the new era and the innovation and entrepreneurship ability required under the background of digital economy. This paper analyzes the problems existing in college students' innovation and entrepreneurship under the background of digital economy, and puts forward corresponding solutions in order to further improve college students' innovation and entrepreneurship ability.