The second hazard of pancreatitis is systemic complications. Organ failure can occur in one or more organs, with different degrees, and severe cases show multiple organ failure. Mainly circulatory failure, manifested as shock. Arrhythmia and heart failure. Acute respiratory failure or acute respiratory distress syndrome is characterized by dyspnea and rapid development of cyanosis, which can not be relieved by conventional oxygen therapy. Acute renal failure is characterized by oliguria, progressive increase of blood urea nitrogen and creatinine. Gastrointestinal bleeding, manifested as hematemesis, black stool or bloody stool, stool occult blood test positive. The spread of infectious diseases can lead to septicemia. In the later stage, due to the extremely low body resistance and the extensive use of antibiotics, fungal infection is prone to occur.