People have also observed the therapeutic effect of hyperthermia on malignant tumors from a large number of clinical practices. Ancient Chinese medicine used garlic-separated moxibustion to treat neck tumors; Ancient western literature also recorded that some people used a red-hot soldering iron to treat body surface tumors. The first medical paper on the contribution of fever to tumor treatment was published in 1866. The author of this paper is German doctor Bush. He reported that a patient with facial tumor confirmed by pathology had a high fever due to erysipelas infection, and the tumor disappeared after the high fever. 1887, Bruns first put forward the idea of applying hyperthermia to tumor treatment.

/kloc-the most famous doctor in the United States at the end of 0/9 century was Cory, who treated tumors by artificially raising his body temperature. He inoculated the cancer patients with Collie toxin, which induced them to have a fever of 42 ℃/24-36 hours, and relieved many patients.