Immunogenetics Laboratory of Shenzhen Blood Center is the "Shenzhen Key Laboratory of Tissue Matching and Immunogenetics Medicine", which undertakes high-tech services, scientific research and teaching and academic exchanges with foreign countries related to tissue matching and immunogenetics. At the same time, it is a high-tech platform based on the Key Laboratory of Tissue Matching and Immunogenetics, namely HLA Laboratory of Guangdong Branch of China Bone Marrow Bank, HLA High Resolution Typing Laboratory of China Bone Marrow Bank, and HLA Quality Control Laboratory of China Bone Marrow Bank (2003-2005), and established the Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Forensic Identification by using molecular biological detection technology of genetic markers of blood type and DNA polymorphism.

Under the guidance of the leadership of the Blood Center, the laboratory has established and developed a high-precision platform for immunogenetics and forensic genetics, systematically carried out the research and application of gene structure and genetic diversity of various blood types in China, and carried out the research and application of various DNA genetic markers and polymorphism detection. There are 1 ABI 3730 and ABI3 100 sequencers in the laboratory, including 1 TECAN DNA workstation, 4 luminox100 flow magnetic bead meters and 1 1 PCR meters. The total price of all kinds of molecular biology and cytology equipment150,000 yuan or more.

Since the Guangdong Branch of China Bone Marrow Bank officially started construction on August 1 2000, more than 30,000 blood samples of hematopoietic stem cell donors have been genotyped, among which 73 voluntary donors in Shenzhen donated hematopoietic stem cells highly compatible with patients' HLA and successfully transplanted them in clinic. The number of hematopoietic stem cells provided by Shenzhen accounts for about 65438 in China. Since 2002, our laboratory has become a high-resolution HLA typing confirmation laboratory of China Bone Marrow Bank through national competition and bidding, and completed 1500 cases of unrelated donor/recipient HLA high-resolution genotyping for transplant hospitals in southern China, without any objection. In 2003-2005, 73 13 quality control samples were re-examined in 25 provincial matching laboratories, and * * * 185 HLA typing error samples were found. Through our HLA quality control work, the quality level of HLA typing in provincial tissue matching laboratories in China has been significantly improved, and it has been highly praised by the national management center of "China Bone Marrow Bank" and colleagues all over the country.

From 2003 to June 2008, * * * undertook municipal projects 10 and 2 provincial projects; Published 77 papers, including SCI papers 13; Four national conferences on immunogenetics were held. Two scientific and technological achievements were obtained, among which "Discovery and identification of three new alleles of human leukocyte antigen (HLA) in China population" won the first prize of Shenzhen Science and Technology Progress Award and the third prize of Guangdong Science and Technology Progress Award in 2003; Another scientific research achievement "Research and Application of Blood Group Gene Structure in China" won the second prize of Guangdong Science and Technology Award in 2006 and the third prize of China Medical Science and Technology Award in 2007, which achieved a historic breakthrough in Shenzhen medical field and the national blood bank system.