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How to make a meta-analysis of two articles
The complete steps of meta-analysis are summarized according meta personal experience and friends' experience. The essence of meta-analysis is the secondary processing and quantitative synthesis of documents, so this summary can be regarded as a meta-analysis of everyone's experience.

First, the topic and the establishment of the topic

(A) the formation of clinical problems to be solved:

Systematic review can solve the following clinical problems:

1. Etiology and risk factors research;

2. Study the effectiveness of treatment methods;

3. Evaluation of diagnostic methods;

4. Prognosis estimation;

5. Patient cost and benefit analysis, etc.

In the initial stage of systematic evaluation, the problems to be solved should be accurately described, including the population type (exact classification and staging of diseases), the type of treatment methods or exposure factors, expected results, etc. Reasonable selection of evaluation indicators.

(2) The choice of index directly affects the accuracy and sensitivity of literature retrieval, and is related to the formulation of retrieval strategy.

(3) Formulating inclusion and exclusion criteria.

Second, literature retrieval

(A) the formulation of retrieval strategy

This is the key and requires a complete and accurate investigation. Mesh combined with free word retrieval is recommended.

(b) literature retrieval, access to abstracts and full texts

There are VIP, CNKI and Wanfang databases in China and medline, SD and OVID in foreign languages.

(3) Document management

It is strongly recommended to use literature management software such as endnote, procite and noteexpress for literature retrieval and management.

The method of searching the full text of literature;

Let's talk about the process of finding documents for the reference of friends behind (excluding those with electronic full text on the Internet):

1. Find free full text:

(1) See if there is any free full text in the postgraduate entrance examination center. Sometimes, although the free full text is not displayed, clicking the full text link will also provide the free full text. I've only met it a few times.

(2) Search in Google.

In rare cases, if NCBI does not provide the full text, Google may find it and use "academic search". Although I can't find a required document in google, I found a very important summary, which contains all the documents I need (not data, of course), but at least one piece of information is provided, which requires so many documents, because the summary of foreigners only contains so much content. In this way, how many documents to look for and what documents to look for will be more emboldened.

(3) Free medical full-text magazine website. Www.freemedicaljournals.com. Provide free full text far beyond the charging period.

2. The library to check the collection catalog:

Including our school, of course. You can use pubmed's linkout to look at the database of literature collection to see if our school has the full text. Other universities in China, such as Fudan University, Peking University and Tsinghua Medical College, have complete full-text databases, which are basically authoritative. In Shanghai, there are libraries in East China and medical schools in China. Here are some examples:

(1) The address of China Association of Medical Libraries of Colleges and Universities is/Xie Hui/chengyuan.htm. Enter "link of current issue" on the left, and you can see "link of current issue" and "link of back issue". Of course, the query results are incomplete and there are many mistakes. I found that the two articles that were the most difficult to find gave the wrong information (later confirmed by phone).

(2) Ask for documents from the email addresses (paid services) of two better libraries, but we can provide documents first and then remit money. Of course, as us, we must pay attention to credibility. 1. :xxbmlpla@sina.com, Information Department of PLA Medical Library, Tel: 01066932429;

(3) Second, Fudan University Medical Library (formerly ):ill@shmu.edu.cn, MD, contact person, Zhou Yueqin, Wang Weizhi, Zheng Rong, telephone number, 02 1-54237822) needs to download the document delivery application form (preliminary, that is, more comprehensive.