Bilirubin comes from hemoglobin in the blood. Once the red blood cells are destroyed, the hemoglobin contained in them will be converted into bilirubin. Although the bilirubin caused by different diseases is different, from a medical point of view, the increase of bilirubin usually represents the decline of liver function and hemolysis of red blood cells, which will have a negative impact on health. The hyperbilirubinemia index detected in this experiment, if normal, has long been judged as abnormal.
But in fact, sometimes in health examination, although bilirubin is high, liver function has not decreased, and there is no abnormal red blood cells. I don't know why the index will increase. However, according to the results of this experiment, we found that bilirubin will increase with the increase of ketone body concentration in blood, which seems to be a normal physiological reaction and can explain some abnormal situations during physical examination.
In addition, the uric acid index has also increased a lot.
From 7. 1 to almost double 13.5. Usually, if the uric acid index exceeds 13.0, it will be diagnosed as hyperuricemia and drug treatment will be started.
But as the director of Japan Anti-aging Medical Research Center &; Bai Ze Zall, MD, Professor of Neurology, University of Michigan, USA (studies molecular genetics of life control genes, molecular biology of Alzheimer's disease, etc. It is still considered that the uric acid index measured in this experiment is high, but it is a normal phenomenon in the transition period.
From many years' experience in treating gout patients, Dr. Bai Zezhuo found that gout attacks have little to do with uric acid. Some people will not cause gout even if the uric acid index is high; On the contrary, some people suffer from gout even if the index is obviously low. Dr Bai Ze often wondered whether the relationship between gout and uric acid was really so absolute. Or are there other factors?
The content of ketone bodies will increase with the deterioration of diabetes, so it also gives people the impression that it was harmful to the body before. However, this is not the fault of ketone body itself, but the glucose can not be metabolized effectively after the deterioration of diabetes, and the body turns to ketone body as an energy source under abnormal circumstances. It is obviously a ketone body made by the body [in order to maintain life], but it is like [eager to help but just staying at the crime scene] but being regarded as the perpetrator.
[Cholesterol can bring arteriosclerosis] is also a misunderstanding that has misled the public for a long time.
The function of cholesterol was originally to inhibit vascular inflammation, but as a result, the inflammation was so serious that it was overloaded and deposited on the blood vessel wall in large quantities, leading to arteriosclerosis.
Ketones and cholesterol are like firefighters who rush to the scene to put out the fire. I didn't expect the fire to get out of hand because I stayed at the scene of the fire and was mistaken for an arsonist.
Neither ketone body nor cholesterol is actually a cause of harm to our health, and bilirubin and uric acid are probably the same. According to the fact that uric acid and bilirubin are rising, we put forward the hypothesis:
Uric acid and bilirubin in blood are antioxidant substances, which can effectively detoxify active oxygen. Among them, uric acid is the strongest antioxidant in blood, accounting for 50% of the total antioxidant capacity in blood.
Uric acid, like vitamin C, has strong antioxidant capacity, that is to say, the increase of uric acid value is not due to illness, but the antioxidant capacity has become stronger.
When ketone bodies are produced in our body, the body is influenced by the running mechanism of ketone bodies, thus enhancing the antioxidant capacity.
Just like AST and ALT mentioned above, some people who are pointed out to be uric acid is too high in health examination may be in an abnormal state of disease, but some may be due to the enhanced antioxidant capacity after ketone bodies are produced in the body, which leads to a combined increase in uric acid index.
There is an interesting paper on uric acid.
When examining the large-scale clinical data presented by Britain, the research class of Harvard Medical School found that patients with gout had a lower risk of developing Alzheimer's disease than those without gout. (as shown)
According to the data of this report, in the follow-up survey, 309 of more than 59,000 gout patients suffered from Atz Harmo disease, while 1924 people without gout suffered from Atz Harmo disease. According to the probability of 65,438+0,000 people getting sick every year, 65,438+0 people will get gout, and 65,438+0.5 people will get Alzheimer's disease without gout.
In addition, the neuroprotective effect of uric acid has also attracted the attention of many scholars in the study of Parkinson's disease and other diseases. If one day we can prove the responsible role of uric acid in the body through research, we can clarify more mysteries about the mechanism of human operation that have been misunderstood or unknown so far, and perhaps we can completely overthrow the cognition of hyperuricemia.