Nifedipine, verapamil, diltiazem? All of them are calcium channel blockers (CCB), which are widely used because of their extensive functions and good clinical effects. But in recent years, its side effects have attracted more and more attention. The common side effects of 1 nifedipine (NF) are headache, dizziness, blushing and insensitivity [1]. Because NF can reduce the pressure of lower esophageal sphincter (LES), some cases have mild epigastric dilatation.