Under the background of the current world economy and the development of China pharmaceutical market, China pharmaceutical enterprises have undergone earth-shaking changes in recent years. Quality management of drug storage and maintenance is an important part of quality management in the process of drug management, which plays an important role in ensuring drug quality. The quality of drug storage and maintenance directly affects the quality of drugs. In practical work, it is necessary to meet the requirements of drug storage and drug quality control. Key words influencing factors of drug storage: Introduction to the classification of special drug storage and maintenance; Quality management of drug storage and maintenance is an important part of quality management in drug management, which plays an important role in ensuring drug quality. The quality of drug storage and maintenance directly affects the quality of drugs. In practical work, it is necessary to meet the requirements of drug storage and drug quality control. I. The main task of drug storage and preservation The main task of drug storage and preservation is to master the changing law of drugs during storage, create suitable storage conditions, take effective measures to maintain the quality of drugs, and maximize the use value of drugs. The basic principle of drug classified storage management is classified storage. Classified storage is to classify drugs into several categories according to their quality characteristics and storage requirements, consistency of different natural attributes, maintenance measures and fire extinguishing methods, and store them in different warehouses respectively, and scientifically store them by district and number. 2. Factors affecting the storage quality of drugs (1) Environmental factors: ultraviolet rays in sunlight play a catalytic role in drug changes and accelerate the oxidative decomposition of drugs. Oxygen and carbon dioxide in the air have a great influence on the quality of drugs. Oxygen easily oxidizes some drugs and makes them deteriorate. Carbon dioxide is absorbed and carbonated by drugs, which makes drugs deteriorate. Humidity The content of water vapor in the air is called humidity. Excessive humidity will cause deliquescence, liquefaction, deterioration or mildew of drugs, while too low humidity will easily lead to weathering of some drugs. The chemical properties of drugs are generally unchanged after weathering, but the dosage is difficult to master when using, especially for highly toxic drugs, which may cause accidents due to exceeding the dosage. Weathering drugs include atropine sulfate, codeine sulfate, magnesium sulfate, sodium sulfate, alum and so on. Most drugs can absorb water vapor in the air and induce dampness evil under the condition of high humidity. Results The drug was diluted, deliquesced, deformed and moldy. Drugs that easily lead to dampness include pepsin, glycerol, etc. If the temperature is too high or too low, the drug will deteriorate. Excessive temperature has a great relationship with the volatilization degree, morphology, oxidative hydrolysis and microbial growth of drugs. If the temperature is too low, it is easy to cause icing or precipitation. Time: Some drugs are unstable because of their nature or efficacy. Even if the storage conditions are suitable, it will gradually deteriorate and fail after a long time. (2) Human factors: staffing; Drug quality supervision and management, such as the establishment, implementation and supervision of drug quality supervision and management rules and regulations; Pharmaceutical personnel's skills in drug storage and maintenance, attention to drug quality, sense of responsibility, physical condition and mental state, etc. (3) Drug itself: Hydrolysis is the main way of drug degradation, and esters (including lactones) and amides (including lactones) are the main degradation drugs. Oxidation is also the most common reaction of drug deterioration. Drugs with phenol, enol, aromatic amine, pyrazolone and thiazine structures are easy to be oxidized. After the drug is oxidized, it not only loses its efficacy, but also may produce color or precipitation. The drugs that are easy to be oxidized should pay special attention to the influence of light, oxygen and metal ions. The packaging materials of drugs also have a great influence on the quality of drugs. (4) Contents of drug appearance inspection: The characteristics of drugs, including shape, color, smell, taste and solubility, are all important contents of drug appearance quality inspection. Different dosage forms have different drug inspection contents. The tablets are uniform in shape, consistent in color, smooth on one side and free from coarse holes; No attached fine powder or particles; No impurities and dirt; The coating is uniform in color and thickness and smooth in surface. After the coating is broken, the particles in the tablet core should be uniform, the color distribution should be uniform and there should be no impurities. The hardness of tablets should be moderate, without abrasion, pulverization, fragmentation and hardness, with normal smell and taste, which conforms to the specific physical properties of drugs. Three. Classified storage management of drugs (1) Classified storage is generally divided into chemical drugs (raw materials and their preparation libraries), Chinese patent medicine libraries, Chinese herbal pieces libraries, Chinese herbal medicine libraries, etc. , generally divided into injection storehouse, tablet storehouse, capsule storehouse, tincture storehouse, syrup storehouse, ointment storehouse, powder storehouse, etc. According to the kind of drugs. (II) Each drug should be stored in cold storage (2 ~ C-l0℃) according to its storage temperature requirements, and the relative humidity of each warehouse in cold storage (not higher than 20℃) or normal temperature storage (0℃~ 30℃) should be kept between 45% and 75%, and it should be stored in the dark according to other requirements of its storage conditions. (3) When drugs are stored according to their nature, the storage method shall be indicated on the package, and the validity period shall be indicated if there is a service period. For example, shading means packaging in an opaque container, which can be a colorless, transparent and translucent container wrapped in brown container or black paper. Sealing means sealing the container to prevent dust and foreign objects from entering. Sealing means sealing the container to prevent weathering, moisture absorption, volatilization or foreign matter from entering. Melting or sealing refers to sealing the container or sealing it tightly with suitable materials to prevent the invasion and pollution of air and water. The shade does not exceed 20 ~. The cold place refers to 2℃ ~ 10℃, the cool and dark place refers to no more than 20℃, and the relative humidity refers to the general control between 60-70%. If the drug packaging or instructions do not indicate the storage method, it should be stored at room temperature (

(eight) effective storage management should implement effective storage management of drugs, and urge the sale of drugs with a validity period of less than 6 months on a monthly basis. Four. Drug maintenance quality management Drug maintenance is a technical work to scientifically maintain the quality of drugs according to the changing law of drugs during storage, and it is a science to study the changing law of stored drugs quality and scientific maintenance methods. (1) The main responsibilities of drug maintenance 1, the provisions on the physical and chemical properties and storage conditions of drugs, and the reasonable storage, storage and maintenance personnel should monitor and manage the temperature and humidity of the warehouse, strictly control the temperature and humidity of the warehouse, prevent drugs from deteriorating, reasonably place a thermometer, objectively reflect the position of the temperature and humidity of the warehouse, and record it regularly every morning and evening. If the temperature and humidity of the warehouse exceed the regulations, 2. Drugs in the warehouse should be regularly maintained and inspected according to their circulation. Generally, the drugs in the warehouse should be counted every month, and the quality and expiration date of the drugs should be checked during the inventory. And do a good job of registration, especially for varieties with short validity and easy to change, the number of inspections should be increased as appropriate. If drugs with suspicious quality are found in inventory maintenance, obvious signs (yellow cards) should be hung to suspend delivery. At the same time, the drug quality inspection notice should be filled in and reported to the quality management agency or the person in charge for timely treatment. According to their characteristics, Chinese herbal medicines or Chinese herbal pieces are cured by drying, oxygen reduction, fumigation and other methods. 3. Regularly summarize, analyze and report the quality information of drugs near the expiration date or stored in the library for a long time. It is necessary to establish drug maintenance files, including: detailed records of drug warehousing, drug maintenance files, maintenance records, inspection report inquiry letters, quality reports, account books, etc. , responsible for the management of maintenance instruments and equipment, and regularly check, maintain and establish files. The expiration date of a drug refers to the period during which the quality of the drug can be maintained under the specified storage conditions. According to the newly revised Drug Administration Law, drugs produced and sold after 200 1, 12, 1 must be marked with the expiration date. Drugs without expiry date shall not be produced or sold. Drug business units should strictly implement the system of urging the sale of expired drugs, and the keeper should fill out the Registration Form of Expired Drugs on a monthly basis. When the drug is only three months away from the expiration date, it belongs to the scope of medical units to urge the sale of expired drugs. If it is estimated that it cannot be completed, it will be postponed. (2) Key conservation varieties 1. Establish a list of key maintenance varieties. For drugs with unstable drug properties, drugs with long storage time, drugs with short-term effects, drugs with special storage requirements, and drugs with quality problems adjacent to the batch number. Perishable varieties in Chinese herbal pieces. For example, varieties that are easy to be moth-eaten, mildew-prone, moisture-absorbing and oily should be specially treated when stored, and a list of key maintenance varieties should be established. 2. Check and control the storage conditions of maintenance drugs with key maintenance contents, conduct quality inspection on drugs regularly, and take effective treatment measures in time for problems found. 3. Maintenance responsibilities and division of labor First of all, quality management personnel are responsible for providing business guidance to drug maintenance personnel, approving maintenance work plans, determining key maintenance varieties, analyzing quality problems reported by drug maintenance personnel and determining treatment measures, and supervising and managing the development of maintenance work. Secondly, the warehouse keeper is responsible for the reasonable storage of drugs in the warehouse, the management of storage conditions such as temperature and humidity between warehouses, and filling out the "Prompt Sales Form for Drugs Near Expiry" every month to assist maintenance personnel in the specific operation of drug maintenance. Finally, the maintenance personnel are responsible for guiding the custodians to store drugs reasonably, regularly checking the storage and quality of drugs in the warehouse, and adopting scientific and effective maintenance methods according to the storage characteristics of drugs. Regularly summarize, analyze and report product maintenance quality information, be responsible for the management of acceptance, maintenance and storage of instruments and equipment, and establish drug maintenance files. 4. Drug Maintenance Archives The establishment of drug maintenance archives refers to monitoring the stability of drug storage quality, summing up maintenance experience, improving maintenance methods and accumulating technical data based on the characteristics of maintenance varieties and based on a certain business cycle. Its contents include: basic quality information of drugs. Tracking records of drug storage quality and handling of related problems during the observation period; Maintain quality information, drug maintenance personnel regularly summarize, analyze and report the contents of maintenance inspection, store the quality information of drugs in the near future or for a long time, and reasonably adjust the quantity of drugs in stock. Ensure that the drugs sold meet the quality requirements. Drug maintenance quality management During the storage process, drugs will change in quality due to the influence of internal or external factors, so drug maintenance is one of the main contents of drug quality management and an indispensable part of drug quality management in the circulation field. V. Management of Special Drugs (I) Management of Unqualified Drugs Unqualified drugs include drugs with unqualified internal quality and drugs with unqualified external quality. If unqualified drugs are found during acceptance and warehousing, the acceptance personnel shall reject them and explain the reasons. If counterfeit drugs, inferior drugs or drugs with major quality problems are found, they shall report to the local drug supervision and administration department. If unqualified drugs are found in warehouse maintenance, the "Drug Quality Re-inspection Form" should be filled in in time, submitted to the drug supervision department and leaders for approval and confirmation, and the sales treatment should be stopped. For unqualified drugs, the reasons should be found out in time. On the basis of finding out the reasons, timely handle and take effective preventive measures, and destroy unqualified drugs when necessary, but register and state in advance, explain the reasons, and properly handle them after approval by the leaders. (II) Administration of Special Drugs The State exercises special administration over narcotic drugs, psychotropic drugs, radioactive drugs and toxic drugs for medical use. , strengthen the management of acceptance, warehousing, storage, outbound audit and sales of specially managed drug buyers. Narcotic drugs and psychotropic drugs of category I shall be kept in special warehouses, and a double-lock storage system shall be implemented when necessary. Special counters should have safety measures, such as alarms and monitors, and the storage conditions should be determined according to the nature of special drugs. Make regular inventory to ensure that the accounts are consistent with the facts. The damaged, deteriorated, expired and unsalable varieties shall be counted and registered, kept separately and properly, and reported to the pharmaceutical supervisory and administrative department for approval before handling, and the handling opinions shall be filed for future reference. Conclusion: Serving people's health is our aim. With the continuous development of economy, the continuous progress of society and the improvement of people's living standards, the demand for drugs is increasing, and the quality of drugs is the most critical foundation. If you want to create greater economic benefits for enterprises, you must do a good job in the custody and maintenance of drugs, think more and learn more, and constantly improve yourself! Based on some current methods and experiences, this paper talks about my own views and opinions, hoping to be more helpful for the future storage and maintenance of drugs. Five years of campus life is coming to an end, and it has come to an end. There are endless sadness and attachment in my heart. Going out from here will be a new journey in my life, and I will apply what I have learned to practical work. Looking back on five years, I have made some achievements, and there are joys and hardships in my life. Thank you for your tireless teaching and concern for my growth in the past five years.

Students are deep and close as brothers and sisters. Four years of ups and downs, we walked together, full of concern, left me with the most cherished memories. In my more than ten years of schooling, I can't live without the encouragement and support of my parents. It is their hard work and selfless dedication that have created good learning conditions for me, allowing me to successfully complete my studies, and I thank them for their constant nurturing and training.

During the internship, I received enthusiastic guidance and selfless help from the leaders of the unit, which made me learn more practical knowledge in this university, and also made me realize the present situation and trend of the pharmaceutical retail industry and really integrate into the pharmaceutical industry. At the same time, I also got great help and support from my colleagues. I would like to express my heartfelt thanks here! Finally, I would like to express my heartfelt thanks to Mr. Cai, who gave us great help and encouragement at the last moment of my graduation, enabling me to successfully complete my graduation project. References: [1] Yang Baofeng. Pharmacology, Beijing: People's Health Publishing House, 9.005.4 10 [2] Edited by Licensed Pharmacists Certification Center of State Administration of Pharmaceutical Products. Beijing: China Traditional Chinese Medicine Publishing House, 2003.242 [3] Xie Bin. Handbook of Practical New Drugs, Beijing: People's Health Publishing House, 2002. 140 [4] Zhou Haiyang, Wang Longxing, Sun Rangchun, et al. Analysis on the influence of "total control and structural adjustment" policy on the healthy development of pharmaceutical industry [J]. China Journal of Hospital Management. Han Liping, et al. Investigation, analysis and management countermeasures of antibacterial drugs in general hospitals [J]. chinese journal of nosocomiology, 2003,13 (2):152-155-[6] Xing, Zhang, Zhang Jianping. North China 18 Hospital antibacterial.