For a long time, it has been controversial in academic circles at home and abroad to use cytological smear or human papillomavirus DNA detection as the primary screening method for cervical cancer. In clinical practice in Europe, it is not recommended to screen women under the age of 35 for human papillomavirus. One of the reasons is overdiagnosis, that is, healthy people are misjudged as cervical cancer or precancerous lesions.
According to reports, this study summarized 17 cross-sectional studies on screening methods for cervical cancer in nine different provinces of China in recent 10 years, involving more than 30,000 women aged 15-59 years, and evaluated the accuracy of screening methods for cervical cancer and precancerous lesions such as iodine acetate staining, liquid-based cytology and human papillomavirus detection.
The results showed that the accuracy of iodine acetate staining and liquid-based cytology varied greatly among different studies, and the repeatability was low. The sensitivity and specificity of high-risk human papillomavirus detection in screening patients with moderate, severe and above lesions in cervical epithelial cells are 97.5% and 85. 1%, which is superior to the above two methods. In addition, among young women under 35 years old, the specificity of high-risk human papillomavirus detection is higher than that of people over 35 years old. If the positive judgment value of high-risk human papillomavirus detection is increased from not less than 1 picogram/ml to more than1picogram/ml, the specificity of the detection result can be improved to 93.5%.
Professor Qiao, the responsible author of this paper, a member of the expert group on cancer prevention and treatment of the World Health Organization, and the director of the epidemic area of the Institute of Cancer of Peking Union Medical College, pointed out that the above research proved that it is effective and feasible to screen cervical cancer and precancerous lesions by using high-risk human papillomavirus DNA detection method with a large number of reliable data. At the same time, it is confirmed that improving the positive judgment value of the virus can effectively reduce the risk of overdiagnosis.
According to reports, at present, the infection rate of high-risk human papillomavirus in urban and rural populations in China is 15.2% and 14.6% respectively, and 99.9% of cervical cancer is caused by high-risk human papillomavirus infection. Joe said that the promotion of human papillomavirus detection technology can maximize the risk of human papillomavirus infection and cancer in patients, and shorten the gap between China and other developing countries and developed countries in the prevention and treatment of cervical cancer.
Editor's Note: The full text of this article is reproduced from June 23rd Health News 165438. Authorities fully affirmed the effectiveness and feasibility of human papillomavirus detection as a primary screening for cervical cancer. It is understood that Ganzhou People's Hospital Branch can do this (HC2- human papillomavirus) test in Gannan at present. Professor Wang Jianzhong, a well-known expert in obstetrics and gynecology in southern Jiangxi and chairman of Ganzhou Obstetrics and Gynecology Committee, said that it is very important for adult women to go to the hospital for gynecological examination regularly every year. Check for HC2 cervical cancer every 3-5 years. Early detection of precancerous lesions and timely treatment will keep women in southern Jiangxi away from cervical cancer.