Project funds:
1. National Natural Science Foundation: Molecular Construction and Biological Activity Evaluation of Novel NO/ pentacyclic Triterpenoids (supported by General Program, 320,000)
2. Natural Science Foundation of Jiangsu Province: Molecular design and activity correlation of triterpenoid derivatives against liver cancer based on NO (supported by general project, 80,000 yuan)
3. Tianjin Natural Science Foundation: Synthesis and Biological Activity of Novel Liver-targeted Triterpenoids Derivatives (ranked second, key project, 200,000).
Results achieved:
1. Two authorized invention patents: 1) Zhang Yihua, Chen Li, Tian Jide and Guo Qinglong. Oleanolic acid coupled derivatives and their medical uses [P].
Awards: The paper "Design, Synthesis and Biological Activity of NO Donor Oleanolic Acid Derivatives" (the first author) 1 won the third prize of excellent papers in the annual meeting of Chinese Pharmaceutical Association (Kunming) (July 2004); 2) Second Prize of Excellent Papers in the 7th National Young Pharmacists' Latest Scientific Research Achievements Exchange Conference (Hangzhou) (2004, 12).
Postgraduate training: 10 independent tutor, two of whom have graduated and are employed in Beijing and Tianjin respectively; At present, there are 8 master students.
Representative papers and achievements
Wang Zhongyuan, Chia Tang and Chen Li *. Research progress of silybin derivatives. Pharmaceutical progress 2009, 8: 360 ~ 364.
, Chen Li *, Kong,,. Synthesis and biological activity of the conjugate of furoxan nitrogen oxide and ferulic acid. Chemical reagent 2008, 4:336-339.
Jiang Feng Chen Ning Xiao Ming. Chemical constituents of Ilex pubescens. Pharmaceutical and Clinical Research 2008,3:163 ~165.
Chen Li, Bi Xiaoling, Luo. Study on synthesis of oleanolic acid ester (Ⅱ). Zhongnan Pharmaceutical 2006,12: 416 ~ 418.
Chen Xiuying, Ji Hui, Zhang Yihua, Chen Li. Protective effect of nitric oxide donor oleanolic acid derivatives on early experimental liver fibrosis. China Journal of Clinical Pharmacology and Therapeutics, 2005,11:121~1268.
Chen Li. Design, synthesis and biological activity of nitric oxide donor oleanolic acid derivatives. The 7th National Exchange Meeting on Latest Scientific Research Achievements of Young Pharmacists (Hangzhou) 2004, 12.
Jiang Liyuan, Li Chen, Zhang Yihua. Improvement of synthesis process of (2- acetoxy) benzoic acid (3- nitroxymethyl) phenyl ester. Chinese journal of medicinal chemistry 2004, 3: 178 ~ 179.
Chen Li. Design, synthesis and biological activity of nitric oxide donor oleanolic acid derivatives. Annual Meeting of Chinese Pharmaceutical Society (Kunming), July 2004.
Chen Li, Kong,. Study on synthesis of oleanolic acid ester (I). Chinese herbal medicine 2003,34 (12):1080 ~101.
Chen Li, Jiang Liyuan, Zhang Yihua. A new synthetic method of NCX- 1000. Pharmaceutical Progress 2003,27 (6): 358 ~ 360.