As the project leader, he has undertaken four national natural science funds, key scientific research projects of the Ministry of Education, outstanding youth funding program of the Ministry of Education, start-up fund for studying abroad of the Ministry of Education, key scientific research projects of Shandong Province, and a number of new drug research and development projects in cooperation with enterprises. Antioxidants such as polyphenols and the prevention of diabetic complications were deeply studied. Systematic study on chemical constituents of bryophytes in China The antifungal activity and antifungal activity of bryophytes were systematically studied, and many new discoveries and breakthroughs were made. The research on nearly 40 kinds of active compounds of animals and plants has been completed, more than one new structural compound 100 has been found, more than 90 academic papers have been published, and nearly 20 papers have been cited by SCI. Three new drugs have obtained new drug certificates, five new drugs have been approved for clinical research, four new drugs are waiting for clinical approval, four new drugs are under research and nine patents are being applied for.

Subject undertaken: National Fund for Distinguished Young Scholars: "Study on the Significance of Chemical Constituents and Biological Activities of Bryophytes" (20 10)

Key project of National Fund: "Discovery of Qualcomm content in bryophytes and preparation of its derivatives" (2008).

National Comprehensive Platform for Major New Drug Creation (2009)

Editor-in-chief published Moss Chemistry and Biology (Science and Technology Press, 20 12) and translated Biosynthesis of Medicinal Natural Products (Paul M Dewick, Chemical Industry Press, 2008). He has published nearly 150 SCI papers in international journals such as Orglett, NAT Prodrep, J NAT Prod, Phytochem, Cancerlett, Bio Medchem, Chem Biochem and Plos One. He has quoted 1000 many times. Authorized 9 patents in China and applied for 1 patents in the United States. Obtained new drug certificates of 2 new drug research projects and clinical approvals of 3 new drug research and development projects. Research direction: active natural products research and new drug development.

1. Moss and medicinal plants contain active terpenoids, polyphenols and alkaloids.

2. Study on the mechanism of antifungal, antitumor and antioxidant effects of natural products.

3. Study on the protective effect of natural antioxidants on cardiovascular system. Qualcomm quantity discovery and derivative preparation of effective components of bryophytes, key project of National Natural Science Foundation (No.30730 109), project leader.

2. research on antifungal activity and antifungal mechanism of dibenzylidene compounds in Diqian (973 plan) (No.2006CB7085 1 1), project leader.

3. research on the inhibition of fungal biofilm formation and reversal of drug resistance by moss components (national natural science foundation project (No.306753 1)), project leader.

4. Study on molecular mechanism of proanthocyanidins induced endogenous antioxidants in cardiomyocytes and antioxidant damage, National Natural Science Foundation of China (No.30472072), project leader.

5. Research on drug resistance reversal agents for major diseases based on sugar recognition, project leader of major science and technology special plan for independent innovation in Shandong Province (No.:2006GG 1 102023).

6. Development of anti-hepatitis drug alkaloid organic acid double salt Y2006C38), Shandong Province, project leader 1. Mei, Guo Huafang, Wang Shuqi, Lou Hongxiang. Separation and identification of two diastereomer pairs in Eupatorium adenophorum by HPLC-circular dichroism detection. Journal of chromatography a, 2007, 1 16 1: 334? 337.

2. Ma Bin, Guo Huaifang and Lou Hongxiang *. A new lignan and two true lignans from LEPIDOPTERA insects. Journal of Helvetica Chimica 2007, 90: 58? 62.

3. Lu Zhiqiang, Guo Huaifang and Lou Hongxiang *. Two kinds of rearranged calamene and eucalyptus sesquiterpenes from China Dihuang. Journal of Helvetica Chimica 2007,90: 52? 57.

4. Feng, Qu Jianbo, Bin Sun, Guo Huaifang and Lou Hongxiang *. An unusual phenylethyl cyclohexanedione extracted from radix rehmanniae. Biochemical systematics and ecology 2007,35:162? 165.

5. Zhu, Qing, Kong Feng, Fan Peihong, Lou Hongxiang. Secondary metabolites of myrrh and its inhibitory effect on human prostate cancer cells. Phytochemistry 2007,68:1331? 1337.

6. Qu Jianbo, Feng, Guo Huaifang and Lou Hongxiang *. Antimicrobial dibenzofuran bis (bibenzyl) s in radix rehmanniae. Phytochemistry 2007,68:1767? 1774.

7. Xing Jie, Feng and Lou Hongxiang *. The latest application of liquid chromatography-mass spectrometry in biological analysis of natural products. Journal of pharmaceutical and biomedical analysis 2007, 44: 368? 378.

8. Zhan Tianrong and Lou Hongxiang *. Synthesis of potential antineoplastic drug d- terpineol pyrrolidine analogues. Carbohydrate research 2007,342: 8695? 8699.

9. Qu Jianbo, Feng, Qiu and Lou Hongxiang *. Water-soluble components of radix rehmanniae. Helvetica Chimica Acta，2007，90: 2 109？ 2 1 15.

10. Zhao Guisen, Liu Chuan, Wang Rui, Song Dandan, Wang Xiaobing, Lou Hongxiang * and Jing Yong Kui *. Synthesis of α, β-unsaturated carbonyl derivatives with inhibition of glutathione S- transferase P 1- 1 activity and proliferation ability of leukemia cells. Bioorganic and bioengineering. Medicinal Chemistry 2007, 15: 270 1? 2707.

1 1. Lei Fang, Guo Huaifang, Lou Hongxiang *. Three new bibenzyl derivatives from radix rehmanniae. 752.

12. Xing Jie, Xie Chunfeng, Qu Jianbo, Guo Huaifang, Lu Beibei, Lou Hongxiang *. Rapid screening of dibenzyl in crude extracts of bryophytes by liquid chromatography-tandem mass spectrometry. Mass spectrometry newsletter 2007,21:2467? 2476.

13. Guo Huaifang, Xing Jie, Feng, Qu Jianbo, Hui, Lou Hongxiang *. Study on dibenzyl in moss by electron ionization time of flight and electrospray ionization triple quadrupole mass spectrometry. Mass spectrometry newsletter 2007,21:1367? 1374.

14. Yu Beibei, Han Xiuzhen, Lou Hongxiang *. Preparation of resveratrol and ferulic acid oligomer by peroxidase catalytic oxidation and their protective effects on myocardial injury. Journal of Agricultural and Food Chemistry 2007,55: 7753–7757.

15. Du Yu, Guo huaifang, Lou hongxiang. Grape seed polyphenols protect myocardial cells from apoptosis by inducing endogenous antioxidant enzymes. Journal of Agricultural and Food Chemistry 2007,55:1695? 170 1. 1. Wang,. Studies on chemical constituents of bryophytes. Advances in natural product chemistry: edited by Yu Dequan and Wu Yulin; Chemical Industry Press: Beijing, 2005; pp 25 1？ 300.

2. Hongxiang Lou, editor-in-chief, Chemistry and Biology of Bryophytes. Beijing Science and Technology Press: Beijing, 2006; pp 1？ 363 ..

3. Hongxiang Lou, Fan Peihong. Tannin. Practical chemistry of natural organic products; Editor-in-Chief Wu Lijun; People's Health Publishing House: Beijing, 2007; Pages 946-983.

4. Benzyl compound 13, 13? -O- isopropylidene substrate yestamine D, its extraction and separation method and application

5. Curcumin phospholipid complex and its preparation method

6. A bibenzyl compound feather E, its extraction and separation method and application.

7. Acetyl salicyl puerarin derivatives, their preparation methods and applications.

8. A total flavone for treating cardiovascular and cerebrovascular diseases, and its preparation method and application.