1, improve liquidity. Generally, the particle size of particles is larger than that of powder, and the number of particles that can be contacted around each particle is small, so the adhesion and agglutination are greatly weakened, thus greatly improving the fluidity of materials. Although substances are solids, they can be treated quantitatively like liquids.

2, to prevent the segregation of each component. Segregation is easy to occur when the particle size and density of each component of the mixture are different, and it can be effectively prevented by granulation after mixing or mixing after granulation.

3. Prevent dust from flying and adhering to the wall. The powder dust is flying and has serious adhesion. After granulation, it can prevent environmental pollution and raw material loss, which is beneficial to GMP management.

Extended data:

Characteristics of common granulation methods:

1, wet granulation: fluidized bed granulation.

The mechanism of particle growth in fluidized bed granulation can be divided into coating growth and agglomeration growth. Coating growth means that the adhesive is spread on the surface of particles in the form of droplets and wrapped layer by layer to make the particles grow; Agglomeration and growth means that two or more particles are gathered together through a liquid bridge or a solid bridge formed by an adhesive to make the particles grow.

2, dry granulation:

Dry granulation means that the powder is compacted into a dense state by applying external force in the granulation process, and the forces that produce stable agglomeration are: bridging force of floc, adhesion force of low viscosity liquid, surface force and cohesion. On the one hand, the success of particle agglomeration depends on the effective utilization and transmission of external forces, on the other hand, it depends on the physical properties of particle materials.

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