In fact, this research work, which won the highest prize in science, was completed by Professor Semenza and his China student Wang Guangliang in the 1990s. Wang Guangliang is the first author of three papers and the second author of 1 paper among the key documents of the prize-winning achievements listed by the Nobel Prize Committee.

20 19 Nobel Prize in Physiology or Medicine was awarded to three scientists in the United States and Britain in recognition of their "contribution to understanding the cell sensing mechanism and adapting to oxygen changes". Among them, Gregg L.Semenza of Johns Hopkins Medical College revealed the regulation mechanism of erythropoietin (EPO), the key hormone for human body to cope with hypoxia.

The transcription factor-hypoxia inducible factor was found. Today, HIF has become a hot target of many drug development, including cancer drugs. Wang Guangliang, a native of Tiantai, Zhejiang Province, 1983 graduated from the biology department of Hangzhou University, and 1986 obtained a master's degree in cell science from China Academy of Sciences. After studying in the United States and obtaining a doctorate, he followed Professor Semenza for postdoctoral research and did a lot of concrete work to discover HIF. On the evening of the 7th, the reporter interviewed Dr. Wang Guangliang, who is now working in a pharmaceutical company in the United States. "I am Mr. Semenza's first postdoctoral researcher. There were only two of us in the whole lab at that time.

When I was looking for HIF, I spent most of my time doing specific scientific research alone. Wang Guangliang recalled the scientific research more than 20 years ago and was still very excited. Semenza has a teaching assignment at Johns Hopkins Medical College. He is also a doctor. He has to treat patients, so a lot of scientific research work is on Wang Guangliang's shoulders. In 20 16, three Nobel Prize winners won the Lasker Prize, an important prize in the biomedical field, for their research on the mechanism of cell perception and adaptation to oxygen changes. After winning the prize, Professor Semenza wrote an article about the process of obtaining this discovery, in which he recalled with emotion Wang Guangliang's excited expression after obtaining HIF protein. The photo published with the article is a photo of Wang Guangliang with a group of scholars such as Professor Semenza and Professor Semenza's mentor, with Wang Guangliang standing in the middle.

In order to devote himself to more practical work, Wang Guangliang later left his laboratory in Semenza to develop in pharmaceutical enterprises. "If I continue to do it in the laboratory and complete more research on the mechanism of cell sensing oxygen with Mr. Semenza, maybe I can share the Nobel Prize with him today."