Later, he was a technician who did oil chemistry experiments in the Central Industrial Laboratory. From 65438 to 0947, he was admitted as a public intern in the United States. First, I worked as an intern in the laboratory of NOPCO Chemical Company in the United States, studying the preparation and analysis of vitamins in oils and fats. Half a year later, he passed the national unified examination for studying in Britain organized by the China-Britain Geng Foundation, and got the opportunity to further his studies. Transferred to the Department of Chemistry, University of Birmingham, UK, majoring in biochemistry. On holidays, he often devotes himself to research projects in the laboratory. /kloc-in the summer of 0/950, the thesis "Research on Glucosamine Chemistry" and "Mannich Reaction" passed the thesis defense and obtained the doctor of science degree. Later, he was hired by the school as a researcher in the Department of Pharmacology, and began his exploration and teaching practice in the field of nervous system drug research. During this period, he found a new compound with local anesthesia effect 10 times stronger than procaine. After the paper was published in the magazine, it attracted the attention of foreign scholars.
1953, just as China stepped into the first five-year plan, Ji Ruyun gave up his generous treatment in a famous British university and resolutely returned to China to participate in the socialist construction of the motherland.
After Ji Ruyun returned to China, under the leadership of Zhao Chengyu, director of Shanghai Institute of Pharmacology, he actively engaged in drug research with Gao Yisheng and others according to the needs of the country, which opened up a new field of new drug synthesis research and made the level of drug research in China leap to a new level. He has made great contributions to the development of Shanghai Institute of Medicine.
In view of the urgent need to prevent and treat schistosomiasis at that time, Ji Ruyun led the research group to carry out the research on schistosomiasis drugs, and synthesized more than 100 experimental drugs against schistosomiasis and parasitic diseases. From 65438 to 0958, the scale of Shanghai Institute of Pharmacology was further expanded. According to the needs of research work, Ji Ruyun launched a research project on nervous system drugs and synthesized nearly 100 experimental drugs, which played a key role in the initiation and development of neuropharmacology research in Shanghai Institute of Pharmacology. 196 1 year, Ji Ruyun led the research on the synthesis of hypertension drugs, synthesized dozens of experimental drugs and conducted various pharmacological experiments. This research was forced to stop due to the Cultural Revolution until the end of 1966.
From 65438 to 0978, Ji Ruyun served as the deputy director of Shanghai Medical Research Institute. With great political enthusiasm and excellent work efficiency, he assisted Director Gao Yisheng to lead the research work of the Institute and manage the scientific research trauma caused by the Cultural Revolution. He personally led a group of academic backbones, and conducted in-depth and detailed research on specialty setting, staffing, equipment purchase, project rectification, and experimental scheme. He answered every detail and carried it out seriously. In addition, he also actively carried out international exchanges and made a lot of work and efforts to expand the influence of China's drug research abroad.
During this period, Ji Ruyun personally served as the head of the research group of medicinal chemistry in the synthesis room, leading the research groups of cardiovascular drugs, antimalarial drugs, nervous system drugs and quantum chemistry, and achieved unprecedented fruitful results in both new drug research and theoretical exploration. 1984, after retiring from the leadership position due to his age, he still served as the leader of the research group "Application of Quantum Chemistry in Pharmaceutical Research".
Ji Ruyun once served as the editorial board of more than ten kinds of magazines, such as Chemical Journal, Pharmaceutical Journal and Pharmaceutical Bulletin, especially devoted a lot of efforts to Foreign Journal of Medicine and Pharmacy, and was his former deputy editor in 1987. In addition, he also serves as the editorial board of DrugoftheFuture magazine. Ji Ruyun is ready to help others academically, paying special attention to supporting and cultivating young people. In addition to his own job, he personally taught in Shanghai Institute of Pharmacology, served as a senior lecturer in pharmaceutical chemistry for graduate students, and was often invited to give short lectures or academic reports in colleges and universities in this city and other provinces and cities.
Ji Ruyun participated in various social activities with great enthusiasm. From 65438 to 0957, he joined the China Democratic League, and later served as the eighth and ninth members of the NLD Central Committee, the seventh member of the NLD Shanghai Municipal Committee, the eighth standing committee and the ninth vice chairman. He also served as the 5th member, 6th standing committee member and 7th standing committee member of Shanghai CPPCC. The fourth member of China Association for Science and Technology, the fourth member of Shanghai Association for Science and Technology, the member of the evaluation team of the Chemical Department of the National Natural Science Foundation Evaluation Committee, and the member of the Shanghai New Drug Evaluation Committee.