It acts as the main donor in the process of HPS, and flavonoids can protect against the harmful effects of free radicals.
Pentoxiflavone was evaluated in the experimental model of biliary liver disease caused by bile duct ligation (BDL) in rats. Pentoxifylline
It was performed on cirrhotic and non-cirrhotic rats at a dose of 50 mg/kg 14 days. Extract bone marrow from animals for analysis.
Lung, liver and blood were extracted, and DNA damage was detected by comet analysis. It turns out that micronucleus and
DNA damage in lung and liver of BDL mice increased. When the decline occurred, pentoxifylline did not cause DNA damage.
Damage of bone marrow micronucleus cells to lung and liver in mice with liver cirrhosis. Pentoxifylline has antimutagenic activity.
According to the bacterial strain (TA 102 Salmonella) sensitive to oxidative stress, the hydroperoxides resistance was evaluated. Salmonella typhimurium and IC203).
Bacillus, it is recommended to prevent free radical ventilation In Saccharomyces cerevisiae, yeast strains lack mitochondria or cytoplasmic superoxide.
These results indicate that pentahydroxyflavone protects cells through antioxidant enzymes. This study is the first report.
The genotoxicity/anti-genotoxicity of pentahydroxyflavone on animal liver disease model. In this model, pentahydroxyflavone did not cause genotoxicity,
On the contrary, it increases the stability of the genome of liver cirrhosis mice, suggesting a beneficial effect, which may be through its antioxidant products.