At present, the treatment strategy for milk protein allergy is still mainly to avoid milk protein and choose deep hydrolysis formula milk powder, which seriously affects the choice of amino acid formula milk, but this method has poor effect. First, it will greatly limit the nutritional intake of infants or children, which will easily lead to malnutrition. In addition, with the emergence of a large number of new food ingredients and genetically modified foods, it is difficult to completely avoid the intake of food antigens. Although the baby with milk allergy can replace hypoallergenic milk powder, it still can't solve the problem of children's allergic constitution.
The specific antiallergic strains contained in Kangminyuan probiotics were developed by the National national cheng kung university Allergy and Clinical Immunology Research Center of Taiwan Province Province. The protective mechanism of Kangminyuan antiallergic probiotics on food allergy. Source: Functionnal Foods (SCI impact factor: 3.47) Abstract: Kangminyuan antiallergic probiotics can reduce the contents of IgE and IgG in serum. Promote the production of IgA, inhibit food allergy symptoms, induce the production of dendritic cells (DCs) of CD 103+, promote the production of regulatory T lymphocytes (Treg), promote intestinal immune balance, and help adjust allergic constitution.
Intestinal IgA mucosal immune response of infants allergic to milk protein has attracted more and more attention in the medical field. Kangminyuan probiotics can induce the generation of CD 103 dendritic cells and promote the expression of IgA. The role of immunoglobulin IgA is to protect intestinal epithelial tissue, so that bacteria, viruses and antigens are not easy to adhere to the surface of intestinal mucosa, thus preventing them from being absorbed. When SIgA is deficient, antigens may invade the body in large quantities, thus achieving oral immune food tolerance-IgA.
Intestinal mucosal immunity and milk protein allergy
There are more and more cases of baby food allergy, and the ability of children's body to prevent antigen invasion is low, mainly for several reasons. Physiologically, the intestinal mucosa forms a physical and immune barrier to prevent allergens and other macromolecules from invading the body.
1. Infants' intestinal digestive and immune functions are not perfect, and there are fewer plasma cells producing secretory IgA in the lamina propria of intestinal mucosa, and the IgA level is low. All kinds of food allergens easily enter the blood through intestinal mucosa, thus causing allergic reactions.
2. The situation of children with food allergy: First, after being stimulated by allergens, the serum IgE antibody of these children has greatly increased, several times or even dozens of times higher than that of normal people. Second, food allergy is often secondary to selective IgA immunoglobulin deficiency. The third point is congenital genetic allergy. Fourth, if food allergy patients eat too much food containing allergic food during pregnancy, the risk of food allergy in their newborns will increase.
Kangminyuan antiallergic probiotics can enhance Treg function induced by CD 103+DCs, and promote IgA surface to regulate food allergic reaction. In view of the protective effect of IgA and Treg on allergic diseases, which is reflected in the regulation of intestinal mucosal immunity and intestinal flora, Kangminyuan antiallergic strain promotes the expression of immunoglobulin IgA, and the immune mechanism of food allergy realizes the process of "oral immune tolerance IgA reconstruction", which provides a new direction for infant food allergy.