196 1, Zou Gang stayed in Shanghai Institute of Pharmacology, Chinese Academy of Sciences after graduation. In addition to continuing to study the mechanism of morphine, he also began to explore ways to find new drugs, especially analgesic drugs in Chinese herbal medicine extracts. He and his colleagues found that there is an alkaloid in Corydalis yanhusuo produced in northern Jiangsu Province that can cause strong and transient convulsions in animals, and its performance is different from that of strychnine, belonging to the supraspinal type. If the filter paper stained with this alkaloid solution is attached to the exposed cerebral cortex, it can cause local spontaneous surface negative waves. At that time, Ecckes reported that strychnine could block the inhibitory postsynaptic potential of spinal cord neurons, but it did not block the inhibitory postsynaptic potential of spinal cord neurons and did not antagonize the inhibitory effect of GABA. Zou Gang and others found that this alkaloid can reverse the effect of GABA on the cerebral cortex, and read this accidental paper at the Dalian meeting of the National Society of Physiological Sciences on 1964. This alkaloid was originally named Su Huxuan base, and later proved to be Bicucukkine. However, due to the beginning of the "Cultural Revolution", the research work was interrupted. 1970, Curtis Laboratory in Australia published the first report in Nature, and Bicucukkine is a specific antagonist of central inhibitory transmitter GABA. The magazine commented that this is a major breakthrough in neuroscience research, and indicated that Bicucukkine will become a powerful weapon for neurophysiologists to analyze central depression. Unfortunately, Zou Gang's discovery in China six years earlier than that abroad was buried in the bud, so the progress of GABA pharmacology was delayed for more than five years. Every time Zou Gang talks about it, he feels very sorry. 65438-0972 The neuropharmacology group with Zou Gang as the main body accepted the research task of acupuncture anesthesia principle assigned by the state. In the process of studying acupuncture analgesia neurotransmitters, Zou Gang, as an organization designer, made a careful plan for the subject, put forward the implementation method, personally established the animal model of the study, and put forward a new idea of the important role of 5- hydroxytryptamine in acupuncture analgesia. In a large number of experiments, 5- hydroxytryptamine was perfused into the brain chamber by isotope labeling, and it was found that the release increased during acupuncture. Chemical destruction of serotonin neurons and fluorescence histochemistry proved that serotonin was indeed necessary for acupuncture analgesia, which played an important role in clarifying the academic debate about whether serotonin participated in acupuncture analgesia at that time. When carrying out this research topic, Zou Gang learned that enkephalins had been found abroad and immediately devoted himself to the study of endogenous opioid peptides. He cooperated with Shanghai Institute of Hypertension to study the changes of enkephalin during acupuncture by radioimmunoassay. It is found that acupuncture increases the release of enkephalins in striatum and hypothalamus, accelerates their synthesis, inhibits their degradation and prolongs the analgesic effect of acupuncture, which proves that there are two kinds of enkephalins involved in acupuncture analgesia. This research won the 1978 National Science Conference Major Achievement Award. This research also won the second prize of Chinese Academy of Sciences 1980, together with the previous research on acupuncture analgesia neurotransmitters. The paper "The Role of Enenkephalin in Acupuncture Analgesia-Radioimmunoassay" co-authored by Zou Gang and his colleagues was recommended for reading at 1979 National Symposium on Acupuncture and Anesthesia and Sino-US Bilateral Pharmacology Symposium held in the United States. During his later visit to the former Federal Republic of Germany and Switzerland, he was invited to give seven speeches and was praised by the participants. Many internationally renowned scholars have actively exchanged academic views with him and invited him to work in foreign laboratories. His paper has reached a high international level, was introduced by current content, and was quoted by many foreign documents.