Db/ol- online database db/mt- tape database m/CD-CD books.
CP/DK- Disk Software J/OL- Online Periodical EB/OL- Online Electronic Advertisement
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NCBI (National Biotechnology Information Center [1]? ) refers to the National Biotechnology Information Center. Understanding the natural silent but subtle language about living cells is the requirement of modern molecular biology. Through the alphabet with only four letters representing the chemical subunits of DNA, the grammar of life process has emerged, and its most complicated form is human beings. Clarifying and using these letters to form new "words and phrases" is the central focus in the field of molecular biology. A large number of molecular data and the hidden and complicated patterns of these data make computerized databases and analysis methods absolutely necessary. The challenge is to find new ways to deal with the quantity and complexity of these data, and to provide researchers with better facilities to obtain tools for analysis and calculation, so as to promote the understanding of our genetic things and their roles in health and disease.
Later, Senator Claude Pepper realized the importance of computerized information processing methods in guiding biomedical research, and initiated the legislation to establish the National Biotechnology Information Center (NCBI) on June 5438+0988165438+1October 4. NCBI is a branch of the National Library of Medicine (NLM) of the National Institutes of Health. NLM is chosen because of its experience in establishing and maintaining bioinformatics database, which can establish an internal research plan on computational molecular biology. The task of NCBI is to develop new information technologies to help understand the basic molecular and genetic processes that control health and disease.
NCBI has a multidisciplinary research team, including computer scientists, molecular biologists, mathematicians, biochemists, experimental physicists and structural biologists, focusing on the basic and applied research of computational molecular biology. These researchers not only make important contributions to basic science, but also often become the source of new methods in applied research activities. Together, they use mathematical and computational methods to study basic biomedical problems at the molecular level. These problems include gene organization, sequence analysis and structure prediction. At present, some representatives of the research plan include: detecting and analyzing gene organization, repetitive sequence form, protein domain and structural unit, establishing gene map of human genome, dynamic mathematical model of HIV infection, analyzing the influence of sequence errors in database search, developing new database search and multiple sequence alignment algorithms, establishing non-redundant sequence database, mathematical model of statistical significance evaluation of sequence similarity and vector model of text retrieval. In addition, researchers of NCBI insist on promoting cooperation with other institutes within the National Institutes of Health, as well as many academic institutions and government research laboratories.