1. Academic contribution: The paper must have an important academic contribution, which can promote the research progress in related fields. This includes putting forward new theories, discovering new experimental results or solving existing problems.

2. Originality: The paper must be original research results, and cannot be a repetition of existing work. The author needs to draw a conclusion through his own experiments, observations or theoretical analysis.

3. Scientific methods: The paper must adopt scientific and rigorous methods for research. This includes reasonable experimental design, accurate data collection and analysis, and reliable result interpretation.

4. Repeatability: The results of this study should be repeatable, and other researchers should be able to get similar results in the same way. This is helpful to verify the reliability and effectiveness of the research.

5. Clear writing: Papers should be written in clear, accurate and concise language. The author needs to transform the complex research content into an easy-to-understand form so that readers can understand and evaluate the importance of the research.

6. Peer review: the paper needs peer review, that is, experts in the same field comment and evaluate the paper. This helps to ensure the quality and academic value of the paper.

7. Meet the requirements of journals: Nature has some specific requirements for papers submitted, such as format and citation specification. Authors need to carefully read and abide by these requirements to ensure that the paper can be accepted and published.

In short, in order to publish a paper in Nature, the author needs to have important academic contributions, original research, scientific and rigorous methods, repeatable results, clear writing, peer review and meet the requirements of the journal. The satisfaction of these conditions will help to improve the quality and academic influence of the paper.