Antibiotics are the most widely used and effective drugs in veterinary clinic, but if misused and abused, it will bring serious harm to biological safety, ecological environment and human health. Therefore, antibiotics must be used reasonably in production, and it is possible to obtain the best safety effect.

(1) Select the most sensitive drug.

According to the drug sensitivity test results of isolated bacteria, the most sensitive drugs were selected for actual control, and the effect was the best. If there are no conditions, we should choose antibiotics with strong action, broad spectrum and low toxicity for prevention and treatment.

(2) Attention should be paid to the combined use and alternate use of antibiotics.

Generally speaking, the combination of drugs can generally improve the curative effect, reduce the side effects and delay the drug resistance of bacteria. Combined medication is generally suitable for: ① serious infection or septicemia with unknown etiology; (2) Mixed infection that drugs can't control; ③ It is easy to be infected by drug-resistant bacteria. Combined medication should also pay attention to the combination of bactericidal drugs (penicillins, cephalosporins, aminoglycosides, etc.). ) or bacteriostatic drugs (tetracyclines, sulfonamides, etc. ) to achieve synergistic or additive effects, such as penicillin and streptomycin, erythromycin and chloramphenicol, sulfonamides and trimethoprim.

(3) Attention should be paid to the relationship between liver and kidney function and antibiotics.

If the liver function is poor, tetracycline, cephalosporin I and chloramphenicol inactivated by liver metabolism should not be used; When the renal function is poor, the dosage of drugs excreted through the kidney should be appropriately reduced or the administration time should be extended to prevent cumulative poisoning caused by excretion disorder.

(4) Analyze the reasons for the failure of antibiotic treatment in time.

The common causes of failure are: ① errors in initial impression diagnosis and bacteriological examination; ② Improper selection of antibiotics; ③ The drugs used are ineffective or insufficient, the course of treatment is too short or the administration method is improper; (4) Drugs cannot reach the damaged organs and tissues or the diseased parts; ⑤ Bacteria develop drug resistance; ⑥ Pigeons have low autoimmune function.